Zhao-quan Wang, R. Löbenberg, L. Sweeney, J. Wong, W. Finlay
{"title":"Improved Drug Delivery: Spray Freeze Dried Nano-Liposomal Inhaled Aerosols","authors":"Zhao-quan Wang, R. Löbenberg, L. Sweeney, J. Wong, W. Finlay","doi":"10.1109/ICMENS.2004.80","DOIUrl":null,"url":null,"abstract":"A novel powder formulation for inhaled aerosol drug delivery of nano-liposomes has been prepared using spray-freeze drying. After saline reconstitution 91% of the liposome particles (mean volume size) were found to be smaller than 600 nm. Upon aerosol dispersion, a fine particle fraction (FPF) of more than 80% was achieved for this formulation with a model drug (ciprofloxacin) using a new passive inhaler (patent pending) at an inhalation flow rate of 60 l/min.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICMENS.2004.80","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
A novel powder formulation for inhaled aerosol drug delivery of nano-liposomes has been prepared using spray-freeze drying. After saline reconstitution 91% of the liposome particles (mean volume size) were found to be smaller than 600 nm. Upon aerosol dispersion, a fine particle fraction (FPF) of more than 80% was achieved for this formulation with a model drug (ciprofloxacin) using a new passive inhaler (patent pending) at an inhalation flow rate of 60 l/min.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
