CPAP insufficiency leads to incomplete centrioles that duplicate but fragment

Abstract

Vasquez-Limeta et al. use human cells engineered for fast degradation of centrosomal protein CPAP. Using superresolution microscopy, they show that CPAP insufficiency leads to centrioles with incomplete microtubule triplets that convert to centrosomes and duplicate, but fragment owing to loss of cohesion between microtubule blades.