{"title":"A three-dimensional microfluidic device for oocyte zona-removal and incubation","authors":"Chuan Chang, Yueh-Jen Chen, L. Pan, F. Tseng","doi":"10.1109/NEMS.2016.7758216","DOIUrl":null,"url":null,"abstract":"To solve the low implantation rate of in-vitro fertilization (IVF), zona-free oocyte is widely used in IVF. However the process of zona-removal is not only tedious but also easy to harm the fragile oocyte. In this work we introduce a 3-dimensional microfluidic device to simplify the zona-removal process, and the applied gentle process is also capable to keep oocyte intact and precisely locate all oocytes in the well throughout the procedure.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2016-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/NEMS.2016.7758216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
To solve the low implantation rate of in-vitro fertilization (IVF), zona-free oocyte is widely used in IVF. However the process of zona-removal is not only tedious but also easy to harm the fragile oocyte. In this work we introduce a 3-dimensional microfluidic device to simplify the zona-removal process, and the applied gentle process is also capable to keep oocyte intact and precisely locate all oocytes in the well throughout the procedure.