Continued Folic Acid Supplementation Throughout Pregnancy, May Cause Colorectal Cancer In The Future

Soroush Niknamian, Vahid Hosseini Djenab, Sora Niknamian
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Abstract

Folic acid supplementation during early pregnancy protects from spina bifida and avoids either a spontaneous miscarriage or a severe developmental defect causing early postnatal death, associated with spina bifida, microcephaly or anencephaly. However, Based on epidemiological data in both the U.S. and Canada showed an increase in the incidence of colorectal cancer beginning when folic acid fortification in wheat-based products became mandatory and continued folic acid supplementation throughout pregnancy can increase the risk of colorectal cancer in the future. Keywords: Pregnancy, Folic Acid Supplementation, Colorectal Cancer, Spina Bifida
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怀孕期间继续补充叶酸,可能会导致结直肠癌
妊娠早期补充叶酸可预防脊柱裂,避免自发流产或严重发育缺陷导致与脊柱裂、小头畸形或无脑畸形相关的早期产后死亡。然而,根据美国和加拿大的流行病学数据显示,当以小麦为基础的产品中叶酸的强化成为强制性规定时,结直肠癌的发病率就开始增加,并且在怀孕期间持续补充叶酸会增加未来患结直肠癌的风险。关键词:妊娠,叶酸补充,结直肠癌,脊柱裂
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