[The influence of ACTH and hydrocortisone on drug kinetics in calves in the example of the antipyrine test].

Abstract

The aim of the experiment carried out on 2 groups (to comprise 8 specimens) bull calves, of ncb. breed, at the age of 60 to 65 days and of an average body weight 90 +/- 5 kg, was to define the effect of intramuscular ACTH (0.2 j.m./kg b.w.) and hydrocortisone (0.2 mg/kg b.w.) injections on the hepatic biotransformation of antipyrine. No changes were noticed in the quantity of antipyrine distribution space Vd under the influence of the hormonal preparations applied. Shorter time of antipyrine halflife from the body T/2 was observed, yet the differences stated have not confirmed statistically. ACTH and hydrocortisone injections caused the increase in constant elimination value of antipyrine from the organism k as well as the increase in the quantity of hepatic antipyrine clearance ClA. The differences observed have not turned out to be statistically significant.