Hormone Therapy in Postmenopausal Women

I. Driscoll, S. Rapp, K. Johnson, M. Espeland
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Abstract

Before 2002, hormone therapy (HT) was commonly prescribed to restore naturally diminishing hormonal levels during and after menopause. HT was also thought to prevent many health conditions faced by menopausal women, including osteoporosis, heart disease, cancer, and dementia. Support for these claims came primarily from epidemiological studies and basic research suggesting biological plausibility. Women now live a third of their life beyond ovarian function cessation. Given that cognitive impairment and dementia increase with age, increasing life expectancy may result in greater public health consequences. This chapter reviews the potential risks and benefits of HT, with a focus on cognitive function. It also discusses the implications of menopausal HT on cognitive impairment and dementia prevention, diagnosis, and treatment for aging women.
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绝经后妇女的激素治疗
2002年之前,激素疗法(HT)通常用于恢复绝经期间和绝经后自然减少的激素水平。人们还认为HT可以预防更年期妇女面临的许多健康问题,包括骨质疏松症、心脏病、癌症和痴呆症。这些说法的支持主要来自流行病学研究和基础研究,表明生物学上的合理性。女性现在有三分之一的生命是在卵巢功能停止后度过的。鉴于认知障碍和痴呆症随着年龄的增长而增加,预期寿命的延长可能导致更大的公共卫生后果。本章回顾了HT的潜在风险和益处,重点是认知功能。它还讨论了更年期激素对老年妇女认知障碍和痴呆预防、诊断和治疗的影响。
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Moving Forward Hormone Therapy in Postmenopausal Women
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