{"title":"[The influence of intratracheal bleomycin instillation on peroxidative processes in rat lung tissue].","authors":"A Ledwozyw, T Ruciński, R Synowiec","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The influence of intratracheally instilled bleomycin (10 mg x kg-1) on antioxidant enzyme activity as well as on lipid peroxidation product levels after 7 and 14 days from drug administration in rat lungs was investigated. The 200-400% increase in superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and glucose-6-phosphate dehydrogenase activities were observed, as compared to control group. The levels of malondialdehyde, conjugated dienes and lipid hydroperoxides in lung tissue of bleomycin-treated rats were also higher than those in control group. These phenomena are the signs of adaptative mechanisms induction in lungs, protecting the tissue from dangerous effect of bleomycin-generated free radicals.</p>","PeriodicalId":20364,"journal":{"name":"Polskie archiwum weterynaryjne","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polskie archiwum weterynaryjne","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The influence of intratracheally instilled bleomycin (10 mg x kg-1) on antioxidant enzyme activity as well as on lipid peroxidation product levels after 7 and 14 days from drug administration in rat lungs was investigated. The 200-400% increase in superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and glucose-6-phosphate dehydrogenase activities were observed, as compared to control group. The levels of malondialdehyde, conjugated dienes and lipid hydroperoxides in lung tissue of bleomycin-treated rats were also higher than those in control group. These phenomena are the signs of adaptative mechanisms induction in lungs, protecting the tissue from dangerous effect of bleomycin-generated free radicals.
研究了气管内灌注博来霉素(10 mg x kg-1)对大鼠肺抗氧化酶活性和给药后7和14 d脂质过氧化产物水平的影响。超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、过氧化氢酶和葡萄糖-6-磷酸脱氢酶活性较对照组提高200-400%。博莱霉素组大鼠肺组织中丙二醛、偶联二烯和脂质氢过氧化物含量均高于对照组。这些现象是肺部适应性机制诱导的标志，保护组织免受博莱霉素产生的自由基的危险影响。
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