The effect of adrenal cortex hormones on heart and skeletal muscles amylases activity under conditions of alpha- and beta-adrenergic stimulation.

Abstract

Influence of hydrocortisone (H), deoxycorticosterone (D), phenylephrine (F) and isoprenaline (I) on activity of alpha amylase (AA) = 4-glucohydrolase alpha-1, 4-glucan [3, 2, 1, 1] and glucoamylase (GA) = glucohydrolase alpha-1, 4-glucan [3, 2, 1, 3] was investigated in heart and skeletal muscle in rats, before and after adrenalectomy (AT). It was found that AT inhibits a rise in the activities of AA and GA caused by F in both investigated muscles, whereas the I given after AT loses its ability to inhibit GA activity in heart and skeletal muscle. Both H and D administered after AT recover the ability of F to an increase in the investigated enzyme activity whereas recovers I ability to inhibit amylase activity in the presence of H. It can be concluded that inhibition of amylase activity is muscles results from interaction between beta-adrenergic stimulation with glucocorticoids, while the increase in activities of these enzymes is a result of interaction between alpha-adrenergic stimulation with mineral tropic action of both D and H.