Evaluation of serum adenosine deaminase activity with reference to dyslipidemia in ischemic heart disease

Sunilkumar S Biradar, Pampareddy B. Kollur, Raghunandana R, Girish M Desai, Netravati B Sajjan
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Abstract

Ischemic health disease is a major health and a modern epidemic which is increasing in India. Dyslipidemia is a major risk factor for atherosclerosis. Serum adenosine deaminase activity is associated with coronary artery disease.The present work was done to understand the relation of serum adenosine deaminase activity with dyslipidemia in ischaemic heart disease.This cross-sectional study comprised 200 subjects; healthy and myocardial infarction. Serum ADA and lipids were estimated. Obtained data was statistically analysed.Increase in serum ADA activity correlating with dyslipidemia was found in Myocardial infarction subjects.Increased ADA has role in LDL oxidation, dyslipidemia, foam cell transformation etc. leading to atherosclerosis and ischemic heart disease. Adenosine deaminase has a crucial role in the evolution of ischemic heart disease through dyslipidemia and coronary artery disease.
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评价血清腺苷脱氨酶活性与缺血性心脏病血脂异常的关系
缺血性疾病是一种主要的健康和现代流行病,在印度呈上升趋势。血脂异常是动脉粥样硬化的主要危险因素。血清腺苷脱氨酶活性与冠状动脉疾病有关。本研究旨在了解缺血性心脏病患者血清腺苷脱氨酶活性与血脂异常的关系。本横断面研究包括200名受试者;健康和心肌梗塞。测定血清ADA和血脂。对所得资料进行统计学分析。心肌梗死患者血清ADA活性升高与血脂异常相关。ADA升高与LDL氧化、血脂异常、泡沫细胞转化等有关,导致动脉粥样硬化和缺血性心脏病。腺苷脱氨酶在缺血性心脏病通过血脂异常和冠状动脉疾病的演变中起着至关重要的作用。
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