Flexible Bayesian modelling of concomitant covariate effects in mixture models

Marco Berrettini, G. Galimberti, Saverio Ranciati, T. B. Murphy
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引用次数: 3

Abstract

Mixture models provide a useful tool to account for unobserved heterogeneity, and are the basis of many model-based clustering methods. In order to gain additional flexibility, some model parameters can be expressed as functions of concomitant covariates. In particular, prior probabilities of latent group membership can be linked to concomitant covariates through a multinomial logistic regression model, where each of these so-called component weights is associated with a linear predictor involving one or more of these variables. In this Thesis, this approach is extended by replacing the linear predictors with additive ones, where the contributions of some/all concomitant covariates can be represented by smooth functions. An estimation procedure within the Bayesian paradigm is proposed. In particular, a data augmentation scheme based on difference random utility models is exploited, and smoothness of the covariate effects is controlled by suitable choices for the prior distributions of the spline coefficients. This methodology is then extended to include flexible covariates effects also on the component densities. The performance of the proposed methodologies is investigated via simulation experiments and applications to real data. The content of the Thesis is organized as follows. In Chapter 1, a literature review about mixture models and mixture models with covariate effects is provided. After a brief introduction on Bayesian additive models with P-splines, the general specification for the proposed method is presented in Chapter 2, together with the associated Bayesian inference procedure. This approach is adapted to the specific case of categorical and continuous manifest variables in Chapter 3 and Chapter 4, respectively. In Chapter 5, the proposed methodology is extended to include flexible covariate effects also in the component densities. Finally, conclusions and remarks on the Thesis are collected in Chapter 6.
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混合模型中伴随协变量效应的柔性贝叶斯建模
混合模型为解释未观察到的异质性提供了一个有用的工具,并且是许多基于模型的聚类方法的基础。为了获得额外的灵活性,一些模型参数可以表示为伴随协变量的函数。特别是,潜在群体成员的先验概率可以通过多项逻辑回归模型与伴随协变量联系起来,其中每个所谓的分量权重都与涉及一个或多个这些变量的线性预测器相关联。在本文中,将该方法扩展为用可加性预测代替线性预测,其中部分/所有伴随协变量的贡献可以用光滑函数表示。提出了一种基于贝叶斯范式的估计方法。特别提出了一种基于差分随机实用新型的数据增强方案,并通过选择合适的样条系数先验分布来控制协变量效应的平滑性。然后将该方法扩展到包括对组件密度的灵活协变量影响。通过仿真实验和对实际数据的应用,对所提出方法的性能进行了研究。论文的内容组织如下:第一章综述了混合模型和协变量混合模型的相关文献。在简要介绍了p样条贝叶斯加性模型之后,第2章给出了该方法的一般规范,以及相关的贝叶斯推理过程。这种方法分别适用于第3章和第4章中分类显变量和连续显变量的具体情况。在第5章中,提出的方法被扩展到包括灵活的协变量效应也在成分密度。最后,第六章是本文的结论和评论。
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Revisiting Empirical Bayes Methods and Applications to Special Types of Data Flexible Bayesian modelling of concomitant covariate effects in mixture models A Critique of Differential Abundance Analysis, and Advocacy for an Alternative Post-Processing of MCMC Conditional variance estimator for sufficient dimension reduction
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