Study on the Incidences of Hypovitaminosis D in Acute Coronary Syndrome Patients

T. Ghose, R. Kachru, Akmal Shams
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Abstract

Aim: Aims of this study was to evaluate vitamin D deficiency as an independent risk factor for acute Coronary Artery Disease and to assess its severity at various aged patients. Methods: A total of 268 patients were included in this study which was an observational cohort study. Based on the inclusion and exclusion criteria, patients who were admitted in the Intensive Coronary Care Unit at Fortis Fit Rajan Dhal Hospital were selected and categorized as male or female and from 18 years upper aged groups such as 21-30 years, 31 to 40 years, 41 to 50 years, 61 to 70, 71-80, 81-90 and above 90 years.  Results: In this study Hypovitaminosis D was higher in male (75.7%) than female (24.3%) and the incidences of Hypovitaminosis D was highest to lowest in the following order; very higher in 51-60 years aged patients (41-50) years aged patients, 61-70 years aged patients, 71-80 years aged patients, 31- 40 years aged patients, 81-90 years aged patients, 21-30 years aged patients and lastly 91-100 years aged patients. From the total incidences only 118 were estimated for normal coronaries, 43 ACS/NSTEMI and 107 for STEMI. Therefore, the representation of vitamin D level severe deficiency ˂ 10 was seen in 47 Normal coronaries individuals, 17 in ACS/NSTEMI and 54 in STEMI. Similarly, deficiency ˂ 20 of vitamin D level was observed in 24 Normal coronaries, 16 in ACS/NSTEMI and 27 in STEMI individuals. Progressively insufficiency (21-29) of vitamin D level has seen in 18 normal coronaries, 3 in ACS/NSTEMI and 18 in STEMI individuals. Lastly normal level of (vitamin D˃30) was seen in 28 normal coronaries, 7 in ACS/NSTEMI and 8 in STEMI individuals. Regularly, hypertension is demonstrated in 57 normal coronaries, 28 in ACS/NSTEMI and 27 in STEMI individuals. Conclusion: There was significant correlation between hypovitaminosis D and coronary artery disease. Consequently, the early detection and management of hypovitaminosis D is essential to control unfavorable cardiovascular events. Recommendation:  Vitamin D supplementation should be given to patients with ACS and cardiac failure will decreases inflammatory indicators and develops health effects.
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急性冠脉综合征患者维生素D缺乏症发生率的研究
目的:本研究的目的是评估维生素D缺乏作为急性冠状动脉疾病的独立危险因素,并评估不同年龄患者的严重程度。方法:本研究采用观察性队列研究,共纳入268例患者。根据纳入和排除标准,从21-30岁、31 - 40岁、41 - 50岁、61 - 70岁、71-80岁、81-90岁和90岁以上的18岁以上年龄组中选择和分类住进富通Fit Rajan Dhal医院冠状动脉重症监护室的患者,分为男性或女性。结果:男性(75.7%)高于女性(24.3%),维生素D缺乏症的发病率由高到低;51 ~ 60岁患者(41 ~ 50岁)、61 ~ 70岁、71 ~ 80岁、31 ~ 40岁、81 ~ 90岁、21 ~ 30岁、91 ~ 100岁)的发病率均较高。在总发病率中,只有118例为正常冠状动脉,43例为ACS/NSTEMI, 107例为STEMI。因此,在47例正常冠状动脉患者、17例ACS/NSTEMI患者和54例STEMI患者中发现了维生素D水平严重缺乏小于10的情况。同样,在24例正常冠状动脉中,16例ACS/NSTEMI患者和27例STEMI患者中,维生素D水平缺乏小于20。18例正常冠状动脉出现维生素D水平进行性不足(21-29),ACS/NSTEMI患者3例,STEMI患者18例。最后,28例冠状动脉正常,ACS/NSTEMI患者7例,STEMI患者8例。通常,57例正常冠状动脉出现高血压,ACS/NSTEMI患者28例,STEMI患者27例。结论:维生素D缺乏症与冠心病有显著相关性。因此,维生素D缺乏症的早期发现和处理对于控制不良心血管事件至关重要。建议:ACS和心衰患者应补充维生素D,可降低炎症指标并对健康产生影响。
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