Central Nervous System Infections Associated with the SARS-CoV-2 Virus

Ferreira Ab, A. As, Davis Vl, Diniz Cg, Cordeiro Dias V
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Abstract

Neurological manifestations in addition to the typical clinical symptoms of COVID-19, have been reported around the world. A case series of clinical suspect of SARS-CoV-2 infection in the central nervous system (n=8) were analyzed. Cerebral Spinal Fluid (CSF) and nasopharyngeal swab were analyzed by RT-PCR. Our results showed SARS-CoV-2 in five CSF samples and three patients testing positive for COVID-19 also on nasopharyngeal swab. The patients showed different clinical manifestations, including <95% saturation, fever, cough, dyspnea and abdominal pain. The findings of this study alert to the existence of nonspecific symptoms associated with central nervous system infection caused by SARS-CoV-2.
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与SARS-CoV-2病毒相关的中枢神经系统感染
除了COVID-19的典型临床症状外,世界各地还报告了神经系统表现。对8例中枢神经系统疑似SARS-CoV-2病例进行分析。采用RT-PCR检测脑脊液和鼻咽拭子。我们的研究结果显示,5份脑脊液样本中含有SARS-CoV-2, 3名患者的鼻咽拭子也检测出COVID-19阳性。患者表现为饱和度<95%、发热、咳嗽、呼吸困难、腹痛等不同临床表现。本研究的发现提醒人们注意与SARS-CoV-2引起的中枢神经系统感染相关的非特异性症状的存在。
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