Pub Date : 2023-10-09DOI: 10.25107/2638-4558-v7-id1614
Sawlani A, Masood R, Bai S, Anwar A
Abstract Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) are two distinct autoimmune disorders characterized by dysregulated immune responses, organ involvement, and the presence of autoantibodies in the bloodstream. Primary Antiphospholipid Syndrome (APS) can occur among individuals who are generally healthy and have no history of an underlying systemic autoimmune illness. In contrast, several other systemic autoimmune diseases, including SLE, have the potential to cause secondary Antiphospholipid Syndrome (APS). While Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) affect women of childbearing age, there are only a few reported case studies documenting the presence of SLE or APS individually in male patients. However, the coexistence of both conditions in a male patient is extremely rare, with only a few documented cases reports available to date. This case report presents a unique occurrence of concurrent SLE and APS in a forty-year-old male patient, highlighting the rarity of such a presentation. The patient presented with per rectal and mucosal bleeding and had been on warfarin therapy for 16 years due to a history of recurrent Deep Vein Thrombosis (DVT), but was not evaluated further. Immune-related laboratory results revealed positive antinuclear antibodies, anti-dsDNA antibodies, anticardiolipin antibodies, lupus anticoagulants, and direct Coombs test. Concurrent SLE and APS were diagnosed by meeting the classification criteria for both diseases. This report adds to the medical literature and emphasizes the significance of considering concurrent SLE and APS as a potential diagnosis in males. Further research is needed to enhance our understanding of the underlying mechanisms and the best approaches for managing this rare coexistence.
{"title":"Systemic Lupus Erythematosus and Anti Phospholipid Syndrome in a Male Patient: A Case Report","authors":"Sawlani A, Masood R, Bai S, Anwar A","doi":"10.25107/2638-4558-v7-id1614","DOIUrl":"https://doi.org/10.25107/2638-4558-v7-id1614","url":null,"abstract":"Abstract Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) are two distinct autoimmune disorders characterized by dysregulated immune responses, organ involvement, and the presence of autoantibodies in the bloodstream. Primary Antiphospholipid Syndrome (APS) can occur among individuals who are generally healthy and have no history of an underlying systemic autoimmune illness. In contrast, several other systemic autoimmune diseases, including SLE, have the potential to cause secondary Antiphospholipid Syndrome (APS). While Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) affect women of childbearing age, there are only a few reported case studies documenting the presence of SLE or APS individually in male patients. However, the coexistence of both conditions in a male patient is extremely rare, with only a few documented cases reports available to date. This case report presents a unique occurrence of concurrent SLE and APS in a forty-year-old male patient, highlighting the rarity of such a presentation. The patient presented with per rectal and mucosal bleeding and had been on warfarin therapy for 16 years due to a history of recurrent Deep Vein Thrombosis (DVT), but was not evaluated further. Immune-related laboratory results revealed positive antinuclear antibodies, anti-dsDNA antibodies, anticardiolipin antibodies, lupus anticoagulants, and direct Coombs test. Concurrent SLE and APS were diagnosed by meeting the classification criteria for both diseases. This report adds to the medical literature and emphasizes the significance of considering concurrent SLE and APS as a potential diagnosis in males. Further research is needed to enhance our understanding of the underlying mechanisms and the best approaches for managing this rare coexistence.","PeriodicalId":247189,"journal":{"name":"Clinical Case Reports International","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-24DOI: 10.25107/2638-4558-v7-id1536
Sarah de O. Rodrigues, Rebecca de O. Rodrigues, Thiago de O. Rodrigues, Jorge P. Pagnossa
Abstract After surgery, intra-abdominal intestinal adhesions present a big problem that is not solved yet. The formation of adhesions begins at the moment when the discontinuity of the peritoneal integrity occurs and the endocrine metabolic response is initiated at a cellular level to repair the defect caused in the peritoneum's surface. However, preventing adhesions from forming in the abdominal portion is considered to be a correlation, from the moment of the execution of the techniques to the total recovery of the patient. Containment measures and the best healing of the tissue can be applied, such as; the use of bio-resorbable membranes and specific dressings emphasized in this analysis. Ensuring stability and a lower probability of the development of the tissular adhesion.
{"title":"Intestinal Adhesions and the Use of Dressings and Bio- Resorbable Membranes as Prevention and Treatment","authors":"Sarah de O. Rodrigues, Rebecca de O. Rodrigues, Thiago de O. Rodrigues, Jorge P. Pagnossa","doi":"10.25107/2638-4558-v7-id1536","DOIUrl":"https://doi.org/10.25107/2638-4558-v7-id1536","url":null,"abstract":"Abstract After surgery, intra-abdominal intestinal adhesions present a big problem that is not solved yet. The formation of adhesions begins at the moment when the discontinuity of the peritoneal integrity occurs and the endocrine metabolic response is initiated at a cellular level to repair the defect caused in the peritoneum's surface. However, preventing adhesions from forming in the abdominal portion is considered to be a correlation, from the moment of the execution of the techniques to the total recovery of the patient. Containment measures and the best healing of the tissue can be applied, such as; the use of bio-resorbable membranes and specific dressings emphasized in this analysis. Ensuring stability and a lower probability of the development of the tissular adhesion.","PeriodicalId":247189,"journal":{"name":"Clinical Case Reports International","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130793345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.25107/2638-4558-v6-id1513
Cerchiaro M, Zanarella S, L. v, Ruggieri P
In pediatric patients, proximal humeral physeal fractures are uncommon injuries compared with distal physeal fractures. Usually, the growth plate is the most vulnerable site of fracture in the proximal humerus. We describe a case of proximal humerus Salter–Harris (S-H) type II physeal fracture in a ten-year- old girl, successfully treated by a minimal trans-deltoid access and fixation with Kirschner (K-wires), under image guidance. She had satisfactory functional outcome 4 months after surgery with painless near total range of motion. Treatment is based on patient age, fracture displacement and remodeling capacity. Nonoperative management is successful in younger patients or in less displaced fractures, while operative management is mostly considered in older patients with more displaced fractures. The majority of pediatric shoulder trauma will result in a good outcome.
{"title":"Salter-Harris Type 2 Fracture of Proximal Humerus Successfully Treated with K-Wire Fixation: A Case Report","authors":"Cerchiaro M, Zanarella S, L. v, Ruggieri P","doi":"10.25107/2638-4558-v6-id1513","DOIUrl":"https://doi.org/10.25107/2638-4558-v6-id1513","url":null,"abstract":"In pediatric patients, proximal humeral physeal fractures are uncommon injuries compared with distal physeal fractures. Usually, the growth plate is the most vulnerable site of fracture in the proximal humerus. We describe a case of proximal humerus Salter–Harris (S-H) type II physeal fracture in a ten-year- old girl, successfully treated by a minimal trans-deltoid access and fixation with Kirschner (K-wires), under image guidance. She had satisfactory functional outcome 4 months after surgery with painless near total range of motion. Treatment is based on patient age, fracture displacement and remodeling capacity. Nonoperative management is successful in younger patients or in less displaced fractures, while operative management is mostly considered in older patients with more displaced fractures. The majority of pediatric shoulder trauma will result in a good outcome.","PeriodicalId":247189,"journal":{"name":"Clinical Case Reports International","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114476450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.25107/2638-4558-v6-id1435
Ferreira Ab, A. As, Davis Vl, Diniz Cg, Cordeiro Dias V
Neurological manifestations in addition to the typical clinical symptoms of COVID-19, have been reported around the world. A case series of clinical suspect of SARS-CoV-2 infection in the central nervous system (n=8) were analyzed. Cerebral Spinal Fluid (CSF) and nasopharyngeal swab were analyzed by RT-PCR. Our results showed SARS-CoV-2 in five CSF samples and three patients testing positive for COVID-19 also on nasopharyngeal swab. The patients showed different clinical manifestations, including <95% saturation, fever, cough, dyspnea and abdominal pain. The findings of this study alert to the existence of nonspecific symptoms associated with central nervous system infection caused by SARS-CoV-2.
{"title":"Central Nervous System Infections Associated with the SARS-CoV-2 Virus","authors":"Ferreira Ab, A. As, Davis Vl, Diniz Cg, Cordeiro Dias V","doi":"10.25107/2638-4558-v6-id1435","DOIUrl":"https://doi.org/10.25107/2638-4558-v6-id1435","url":null,"abstract":"Neurological manifestations in addition to the typical clinical symptoms of COVID-19, have been reported around the world. A case series of clinical suspect of SARS-CoV-2 infection in the central nervous system (n=8) were analyzed. Cerebral Spinal Fluid (CSF) and nasopharyngeal swab were analyzed by RT-PCR. Our results showed SARS-CoV-2 in five CSF samples and three patients testing positive for COVID-19 also on nasopharyngeal swab. The patients showed different clinical manifestations, including <95% saturation, fever, cough, dyspnea and abdominal pain. The findings of this study alert to the existence of nonspecific symptoms associated with central nervous system infection caused by SARS-CoV-2.","PeriodicalId":247189,"journal":{"name":"Clinical Case Reports International","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129236142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-30DOI: 10.22541/AU.161203349.96268572/V1
M. Adel, M. Mashaal, K. Mahmoud, S. Mashhour, H. Soliman
We report a case of superior vena cava obstruction of a 39 years old female patient with primary antiphospholipid syndrome presented with upper limb pain and swelling ,which improved on thrombolytic therapy ,we review patients with Antiphospholipid syndrome and management with thrombolytic therapy .
{"title":"Superior vena cava obstruction with thrombolytic therapy in primary antiphospholipid syndrome","authors":"M. Adel, M. Mashaal, K. Mahmoud, S. Mashhour, H. Soliman","doi":"10.22541/AU.161203349.96268572/V1","DOIUrl":"https://doi.org/10.22541/AU.161203349.96268572/V1","url":null,"abstract":"We report a case of superior vena cava obstruction of a 39 years old\u0000female patient with primary antiphospholipid syndrome presented with\u0000upper limb pain and swelling ,which improved on thrombolytic therapy ,we\u0000review patients with Antiphospholipid syndrome and management with\u0000thrombolytic therapy .","PeriodicalId":247189,"journal":{"name":"Clinical Case Reports International","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125577654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-30DOI: 10.25107/2638-4558-v3-id1121
Mai D. Gandhi, B. Welch, S. Luster, Noman Khan
Despite lifestyle modification and weight-loss programs, the obesity epidemic is on the rise. A variety of new laparoscopic and endoscopic techniques exist to aid in the weight loss process, with some of the newest advances in intra gastric balloons. In this case report, we aim to answer the question of whether the Air-filled Gastric Balloon System can act as a bridge to definitive bariatric surgery, as an off-label use, in patients with a BMI greater than 65 kg/m2. Mai Gandhi*, Brian Welch, Stephanie Luster and Noman Khan Department of Surgery, Flushing Hospital Medical Center, USA Mai Gandhi, et al., Clinical Case Reports International Surgery Remedy Publications LLC., | http://clinicalcasereportsint.com/ 2019 | Volume 3 | Article 1121 2 gastric balloon system.
{"title":"Case Report: An Off-label Use of the Air-filled Gastric Balloon System as an Adjunct to Bariatric Surgery","authors":"Mai D. Gandhi, B. Welch, S. Luster, Noman Khan","doi":"10.25107/2638-4558-v3-id1121","DOIUrl":"https://doi.org/10.25107/2638-4558-v3-id1121","url":null,"abstract":"Despite lifestyle modification and weight-loss programs, the obesity epidemic is on the rise. A variety of new laparoscopic and endoscopic techniques exist to aid in the weight loss process, with some of the newest advances in intra gastric balloons. In this case report, we aim to answer the question of whether the Air-filled Gastric Balloon System can act as a bridge to definitive bariatric surgery, as an off-label use, in patients with a BMI greater than 65 kg/m2. Mai Gandhi*, Brian Welch, Stephanie Luster and Noman Khan Department of Surgery, Flushing Hospital Medical Center, USA Mai Gandhi, et al., Clinical Case Reports International Surgery Remedy Publications LLC., | http://clinicalcasereportsint.com/ 2019 | Volume 3 | Article 1121 2 gastric balloon system.","PeriodicalId":247189,"journal":{"name":"Clinical Case Reports International","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125450430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Bresciani, Lozano Tsp, Benitez Adn, Sakamoto, Romano Jfb, Stoppe Cv, J. M. Ferreira, Santos Jcd, Silva Tcc, J. Gomes
Congenital toxoplasmosis is a neglected protozoonotic disease of intercontinental distribution with incidence estimated in 1.5 cases per 1000 live births. This infection can be acquired intrauterine when the first infection of pregnant woman occurs and the Toxoplasma gondii reaches the fetus by transplacental via. The damage to the fetus can compromise the pregnancy and life quality of the infected individual. Early diagnosis of infection allows emergency therapeutic intervention with reduction of the transmission rate and also the severity of the sequelae. Different methodologies are available for the diagnosis of acute gestational toxoplasmosis with detection of IgG and IgM anti-T. gondii antibodies. The methodologies differ mainly by specificity and sensitivity values reached, as well as execution facility and time required. These parameters can decisively influence the choice of the most appropriate technique by the municipal health polices, in public health strategies. The main of the present review is to synthesize the major characteristics of serological tests for congenital toxoplasmosis.
{"title":"Major Serological Screening Methodologies to Anti- T. Gondii Antibodies Detection in Pregnancy: Mini Literature View","authors":"K. Bresciani, Lozano Tsp, Benitez Adn, Sakamoto, Romano Jfb, Stoppe Cv, J. M. Ferreira, Santos Jcd, Silva Tcc, J. Gomes","doi":"10.25107/CCRI-V2-ID1079","DOIUrl":"https://doi.org/10.25107/CCRI-V2-ID1079","url":null,"abstract":"Congenital toxoplasmosis is a neglected protozoonotic disease of intercontinental distribution with incidence estimated in 1.5 cases per 1000 live births. This infection can be acquired intrauterine when the first infection of pregnant woman occurs and the Toxoplasma gondii reaches the fetus by transplacental via. The damage to the fetus can compromise the pregnancy and life quality of the infected individual. Early diagnosis of infection allows emergency therapeutic intervention with reduction of the transmission rate and also the severity of the sequelae. Different methodologies are available for the diagnosis of acute gestational toxoplasmosis with detection of IgG and IgM anti-T. gondii antibodies. The methodologies differ mainly by specificity and sensitivity values reached, as well as execution facility and time required. These parameters can decisively influence the choice of the most appropriate technique by the municipal health polices, in public health strategies. The main of the present review is to synthesize the major characteristics of serological tests for congenital toxoplasmosis.","PeriodicalId":247189,"journal":{"name":"Clinical Case Reports International","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121172390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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