Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway

Zheng Wang, Di Chen, Dongshi Guan, Xiaobo Liang, Jianfeng Xue, Hongyu Zhao, G. Song, J. Lou, Yan He, Hong Zhang
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引用次数: 17

Abstract

Protein condensates possess distinct material properties. Wang et al. show that the material properties of TFEB condensates govern their size and transcriptional activity. These properties can be manipulated to modulate the activity of TFEB in the autophagy-lysosome pathway.
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相分离TFEB凝聚物的材料特性调节自噬-溶酶体途径
蛋白质凝聚物具有独特的物质特性。Wang等人的研究表明,TFEB凝聚物的材料性质决定了它们的大小和转录活性。这些特性可以调节TFEB在自噬-溶酶体途径中的活性。
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