E. Lambert, Elodie Barthout, R. Manczak, S. Saada, Lea Ikhlef, R. Formento, M. Verdier, C. Dalmay, B. Bessette, F. Lalloué, A. Pothier
{"title":"Biological Cell Characterization and Discrimination Based on UHF-Dielectrophoresis for Next Generation of Liquid Biopsy Analysis","authors":"E. Lambert, Elodie Barthout, R. Manczak, S. Saada, Lea Ikhlef, R. Formento, M. Verdier, C. Dalmay, B. Bessette, F. Lalloué, A. Pothier","doi":"10.1109/imarc49196.2021.9714586","DOIUrl":null,"url":null,"abstract":"This paper introduces results about characterizations of different tumor cell lines, using intracellular sensing based on Ultra High Frequency dielectrophoresis (UHF-DEP). Above 50 MHz, presented technic allows to probe internal cell content to characterize its cytoplasm permittivity and conductivity properties. The measured frequency-dependent cell behavior results on a distinctive DEP signature according to the cell type and its biological specificity. This paper illustrates the high potential of UHF lab-on-chip sensor to discriminate various tumor cell types derived from different tissues.","PeriodicalId":226787,"journal":{"name":"2021 IEEE MTT-S International Microwave and RF Conference (IMARC)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2021 IEEE MTT-S International Microwave and RF Conference (IMARC)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/imarc49196.2021.9714586","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This paper introduces results about characterizations of different tumor cell lines, using intracellular sensing based on Ultra High Frequency dielectrophoresis (UHF-DEP). Above 50 MHz, presented technic allows to probe internal cell content to characterize its cytoplasm permittivity and conductivity properties. The measured frequency-dependent cell behavior results on a distinctive DEP signature according to the cell type and its biological specificity. This paper illustrates the high potential of UHF lab-on-chip sensor to discriminate various tumor cell types derived from different tissues.