[Lipid peroxidation in dog lung microsomes].

Polskie archiwum weterynaryjne Pub Date : 1991-01-01
A Ledwozyw, A Kadziołka
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Abstract

The changes in lipid composition of dog lung microsomes during Fe3+/NADPH-induced peroxidation and correlation between malondialdehyde production and polyunsaturated fatty acids consumption were investigated. It was shown, that microsomal peroxidation causes phosphatidylcholine and phosphatidylethanolamine content decrease, with concomitant increase in lysophosphoglyceride content. Malondialdehyde production intensity was correlated with arachidonic and docosahexaenoic acid consumption. The changes thus observed, may be engaged in pathogenesis of respiratory distress syndrome.

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[狗肺微粒体脂质过氧化]。
研究了Fe3+/ nadph诱导的狗肺微粒体过氧化过程中脂质组成的变化以及丙二醛生成与多不饱和脂肪酸消耗的相关性。结果表明,微粒体过氧化可导致磷脂酰胆碱和磷脂酰乙醇胺含量降低,同时溶血甘油酯含量升高。丙二醛生产强度与花生四烯酸和二十二碳六烯酸消耗量相关。由此观察到的变化,可能与呼吸窘迫综合征的发病机制有关。
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