Oxidative stress and antioxidant enzyme levelsin the blood serum of white mice when exposed to iron and manganese in drinking water under experimental conditions

Abstract

The object of the study of enzymatic antioxidants in the blood serum of white mice were 30 outbred white male and female mice of the same age and approximately of the same weight. The animals were divided into 3 groups: one control group and two experimental ones in which the mice consumed water with a high content of total iron and manganese (II) ion (over 5 MPC).This study revealed that the activity of glutathione transferase as a marker of antioxidant defense increased among the male mice in the experimental group after experiencing a 12-week-long intoxication, however the level of malondialdehyde in their blood serum indicated insignificant oxidative stress. Keywords: iron, manganese, drinking water, glutathione transferase, malondialdehyde, antioxidant defense, oxidative stress.