Peptide-mediated pathogenesis of Alzheimer's disease

Abstract

This chapter discusses molecular mechanisms involving proteins of three main classes – tau proteins, amyloid-β and presenilins – that lead to the symptoms characteristic of the Alzheimer's disease. A particular focus is placed on primary structure modifications, conformations and conformational transitions of these proteins. The work highlights specialist research findings published over the last few years to the time of its submission. The reviewed literature is sourced from different databases including Web of Science, RCSB Protein Data Bank and PubMed. A reference to background information is also provided to cover an unlimited timeframe. Individual sections are arranged according to each of the three proteins, emphasising the mechanistic implications of each protein in the neuropathology of AD.