1.3 The development of high-speed DNA sequencing: Jurassic Park, Neanderthal, Moore, and you

J. Rothberg
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Abstract

Since Watson and Crick's 1953 landmark discovery that biological information was encoded in DNA as a sequence of chemical building-block “letters”, developing technology for reading (or “sequencing”) this chemical code has been fundamental to advances in biology and medicine. Techniques that first enabled this were invented by Sanger in 1978, and were taken to massively parallel form by 454 Life Sciences in 2003 [1]. This ushered in the current or “next-gen” era of genome sequencing technologies for research, medicine, and the emerging field of Genomic-Personalized Medicine, in which healthcare is more fully informed by the individuals' personal genetic makeup.
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1.3高速DNA测序的发展:侏罗纪公园、尼安德特人、摩尔和你
自从沃森和克里克1953年里程碑式的发现生物信息在DNA中被编码为一系列化学构件“字母”以来,开发读取(或“测序”)这种化学密码的技术一直是生物学和医学进步的基础。桑格在1978年发明的技术首次实现了这一目标,并在2003年被454生命科学公司采用了大规模的平行形式。这开启了基因组测序技术用于研究、医学和基因组个性化医学新兴领域的当前或“下一代”时代,在这个领域,医疗保健更充分地了解个人的个人基因构成。
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