Neural fate decisions mediated by notch-delta signaling

Abstract

In the developing nervous system, the expression of proneural genes, i.e., Hes1, Neurogenin-2 (Ngn2), and Deltalike-1 (Dll1), oscillates in neural progenitors with a period of 2–3 h, but is persistent in postmitotic neurons. In this paper, we present a computational model for neural fate decisions based on intertwined Notch-Delta signaling involving the Hes1, Notch, and Dll1 proteins. In agreement with experimental observations, the model predicts that Notch-Delta signaling plays critical roles in regulating the choice between remaining as a progenitor and embarking on neural differentiation.