Antibacterial Effects of Crude Lectin Fraction Bioactive Compound of Red Macroalgae P. palmata and H. glandiforme from Southern Coast Java Island, Gunungkidul, Yogyakarta, Indonesia

Abstract

Lectins or carbohydrate-binding proteins, are widely distributed in nature and also good candidates in such prospecting of algae. It may have been considered that binding specificity of lectins to some carbohydrates provokes to produce many unique biological activities, including cell agglutination, mitogenic activity, antibacterial activity and antitumor activity. The aim of this study was to determine the antibacterial effect of crude lectins fractions from red macro algae collected from the southern coast of Java island, Gunung Kidul Regency, Yogyakarta Indonesia. The.Crude lectin fraction showed no antibacterial activity against gram-negative bacteria because most of bacteria cells surface contain of mannan glycoprotein and the sample has no specificity to bind this glycoprotein type. Crude lectin fraction tested also have no antibacterial effect aginst gram positife bacteria because only binding specifically to N-glycan specifically as well as O-glycan.