Environmental Phthalate Exposure in Relation to Reproductive Outcomes and Other Health Endpoints in Humans

Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution Pub Date : 1900-01-01 DOI:10.4018/978-1-5225-9452-9.CH016

Sameena, Riyes Un Aziz, Aubid Bashir

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引用次数: 8

Abstract

Phthalates are the class of chemicals that exhibit numerous adverse effects to health. These non-persistent chemicals are produced in high volume annually and are used in a wide array of industrial consumer products. The overall exposure of phthalates to humans is via ingestion of contaminated food from wrapped materials or dermally via consumer care products. Pthalates are anti-androgenic compounds, so for this reason, they obtrude with the expression of testosterone by manipulating gene expression of proteins and enzymes involved in production of testosterone. The primarily exposure of Pthalates during fetal development stage results in number of harmful effects in male offspring in humans, like abnormalities of the sperm-producing organs, abnormal development of penile, hypospadias, reduced anogenital distance, as well as a risk for prostate cancer and cryptorchidism. The purpose of this chapter was to review the environmental impact of phthalate exposure in relation to reproductive behavior and other health problems in humans.

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环境邻苯二甲酸盐暴露与人类生殖结果和其他健康终点的关系

邻苯二甲酸盐是一类对健康有许多不利影响的化学物质。这些非持久性化学品每年大量生产，并广泛用于各种工业消费品。人类接触邻苯二甲酸盐的总体途径是通过从包装材料中摄入受污染的食物或通过消费者护理产品的皮肤接触。邻苯二甲酸盐是抗雄激素化合物，因此，它们通过操纵与睾丸激素产生有关的蛋白质和酶的基因表达来干扰睾丸激素的表达。胎儿发育阶段接触邻苯二甲酸盐会对人类男性后代造成许多有害影响，如精子产生器官异常、阴茎发育异常、尿道下裂、肛门生殖器距离缩短，以及患前列腺癌和隐睾的风险。本章的目的是审查接触邻苯二甲酸盐对人类生殖行为和其他健康问题的环境影响。

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Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution

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