Antimicrobial, Anticancer, Antioxidant Potential of Pyridine based Coordination Compounds: In-silico ADMET Prediction and Molecular Docking Simulations

Abstract

The novel Schiff base metal complexes were derived from the reaction of 9-anthraldehyde and 2-amino-3-hydroxypyridine and metal chlorides All the compounds were investigated by various spectral analysis. From the analysis, it is clear that compounds have square planar geometry with crystalline look. The DNA synergic studies suggest that the compounds were better DNA binder. The synthesized compounds were screened against several microbes which specified that the compounds have greater screening ability than ligand due to chelation. The anticancer activity of the synthesized compounds was also studied which revealed that the Cu(II) has greater potential rather than other compounds. The antioxidant ability display that the synthesized compounds have excellent ability to destroy the free radical than ligand. The ADMET evaluation shows that the prepared compounds hold good drug-likeness skill.