Application of cellular technologies in the treatment of chronic pain ofthe lumbar spine

Abstract

The paper presents the results of clinical testing of autologous cells of the stromal vascular fraction (SVF) mesenchymal stromal cells in patients with deforming spondyloarthrosis of the lumbar spine. The study selected 20 patients aged 45 to 85 years with symptoms of degenerative spondyloarthrosis of the lumbar spine confirmed by radiological methods (CT, MRI, X-ray), 5 men, 15 women, average age 64.7 years with a disease duration of 5 years. Autologous SVF cells were injected into the affected facet joints under the control of an electron optical converter. The introduction of SVF cells did not cause the development of inflammatory allergic and toxic reactions. Patient survey conducted 1 month after the introduction of SVF cells revealed a decrease in the severity of pain syndrome, assessed on a visual analog scale (VAS) and a specialized SF-36 scale (p<0.05 on both scales). Patients noted an improvement in functional activity and quality of life associated with the affected facet joints. Positive clinical dynamic was maintained during follow-up up to 6 months. The control magnetic resonance imaging after 6 months revealed no significant differences from the initial examination. Our study showed the safety and good tolerability of the introduction of autologous SVF cells into the areathe zygapophysial (facet) of facet joints. Our study showed the safety and good tolerability of the introduction of autologous SVF cells into the area of the Lumbar Facet Joint Injectionsin patients with severe manifestations of deforming spondyloarthrosis. The obtained results also indicate a significant anti-inflammatory effect of autologous SVF cells of adipose tissue at the early stages of cell therapy.