{"title":"Gene Expression Changes in the Human Brain Upon Aging","authors":"Lilach Soreq","doi":"10.47363/jnrrr/2022(5)169","DOIUrl":null,"url":null,"abstract":"Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.","PeriodicalId":309719,"journal":{"name":"Journal of Neurology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurology Research Reviews & Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47363/jnrrr/2022(5)169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
