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Characterization of Adult Patients with Pilocytic Astrocytoma with an Aggressive Clinical Course. Retrospective Cross-Sectional Study. Single Center Experience 具有侵袭性临床表现的嗜酸性粒细胞星形细胞瘤成人患者的特征。回顾性横断面研究。单中心经验
Pub Date : 2024-03-31 DOI: 10.47363/jnrrr/2024(6)197
Konovalov Na, Usachev Du, Kaprovoy Sv, Ilyinski N, Poluektov Ym
Background: Pilocytic astrocytoma (PA) is a common tumor of the central nervous system and is considered a benign condition. However, in some cases PA can have an aggressive clinical behavior. Aim: To analyze and correlate factors leading to an aggressive course of disease in patients with Pilocytic astrocytoma.
背景:嗜酸性粒细胞星形细胞瘤(PA)是中枢神经系统的一种常见肿瘤,被认为是一种良性疾病。然而,在某些情况下,PA 可能具有侵袭性临床表现。目的:分析导致嗜酸性粒细胞星形细胞瘤患者病情恶化的相关因素。
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引用次数: 0
Epidemiological, Clinical and Etiological Aspects of Urinary Sphincter Disorders of Neurological Origin at Conakry University Hospital 科纳克里大学医院神经性尿道括约肌疾病的流行病学、临床和病因方面
Pub Date : 2024-03-31 DOI: 10.47363/jnrrr/2024(6)196
Bangoura M A, Toure M L, Camara B D B, Traore M, Camara I A
Introduction: Most neurological disorders in our context have a high frequency of urinary sphincter disorders, which makes it necessary to investigate the etiologies and analyze the epidemio-clinical features.
导言:在我国,大多数神经系统疾病都会导致尿道括约肌功能紊乱,因此有必要对其病因进行调查,并分析其流行病学-临床特征。
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引用次数: 0
Screening for Depression among Medicyation Overuse Headache Patients and its Treatment could be useful for Improving their Quality of Life 对过度用药头痛患者进行抑郁筛查和治疗有助于提高他们的生活质量
Pub Date : 2024-02-29 DOI: 10.47363/jnrrr/2024(6)195
Ljubisavljevic Srdjan, Todorovic Stefan, Djokovic Filip
Background: The negative impact of medication overuse headache (MOH) on the quality of life (QoL) of the patient is undoubted. Objective: The aim of this study was to identify clinical and headache related parameters that directly affect HRQoL of MOH patients.
背景:药物滥用性头痛(MOH)对患者生活质量(QoL)的负面影响毋庸置疑。研究目的本研究旨在确定直接影响过度用药头痛患者生活质量的临床和头痛相关参数。
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引用次数: 0
Cognitive Frailty: Frequency and Risk of Adverse Events in Older Individuals 认知虚弱:老年人发生不良事件的频率和风险
Pub Date : 2024-02-29 DOI: 10.47363/jnrrr/2024(6)194
Caroline Delboni Nascimento, Ingrid Ardisson Coledete, Fernanda Nicoli Souza, Luiza Moraes Miossi, Renato Lirio Morelato
Objectives: To analyze the associated cognitive frailty with falls and clinical admissions in older patients. Methods: Case-control, analytical, individual-based, observational study based on longitudinal retrospective design. The sample comprised patients older than 65 years old, treated at the outpatient clinic of a geriatric service, who were followed up in the previous period of six months. Cognitive frailty (CF) was used as a dependent variable in the present study. Cognitive impairment was diagnosed based on Clinical Dementia Rating. Frailty was categorized based on the clinical frailty scale. The Chi-square test and Poisson regression model were used to evaluate the association between CF and outcomes.
目的分析认知虚弱与老年患者跌倒和临床入院的相关性。方法:病例对照、分析、基于个体的观察性研究,采用纵向回顾设计:病例对照、分析、基于个体的观察性研究,采用纵向回顾设计。样本包括 65 岁以上、在老年病科门诊接受过治疗的患者,并对他们进行了为期 6 个月的随访。认知虚弱(CF)是本研究的因变量。认知功能障碍根据临床痴呆评级进行诊断。虚弱程度根据临床虚弱量表进行分类。研究采用卡方检验和泊松回归模型来评估认知虚弱与结果之间的关系。
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引用次数: 0
Case Report: Complete Resection of a Primary Intraosseous Meningioma in A 15-Year-Old Boy in Mexico, A Rare Entity 病例报告:墨西哥一名 15 岁男孩的原发性骨内脑膜瘤全切除术,罕见病例
Pub Date : 2024-01-31 DOI: 10.47363/jnrrr/2024(6)193
Isaias Perez Negrete
Meningiomas are among the most common primary benign tumors and most of them are primary intradural lesions located in the subdural space. According to Casas-Perera et al., they represent 36.4% of the primary intracranial tumors. Meningiomas may be incidental, small, and slow growing tumors or extensive and/or rapidly progressive growing masses. There is a subset of meningiomas that arise outside the intradural space, called Primary Extradural Meningiomas (PEM) which, as the name suggest, develop outside the intracranial compartment and in this myriad of locations, Primary Intraosseous Meningiomas (PIOMs) are considered an uncommon type of PEMs that constitute up to 2% of meningiomas overall.
脑膜瘤是最常见的原发性良性肿瘤之一,其中大部分是位于硬膜下间隙的原发性硬膜内病变。根据 Casas-Perera 等人的研究,它们占原发性颅内肿瘤的 36.4%。脑膜瘤可能是偶发的、小的和生长缓慢的肿瘤,也可能是广泛和/或快速进展性生长的肿块。原发性硬膜外脑膜瘤(Primary Extradural Meningiomas,PEM),顾名思义,是在颅内腔外生长的脑膜瘤,在这无数的位置中,原发性骨内脑膜瘤(Primary Intraosseous Meningiomas,PIOMs)被认为是一种不常见的脑膜瘤类型,占脑膜瘤总数的 2%。
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引用次数: 0
Correlation between the Profile of Intracranial Hemorrhages Resulting from Traumatic Brain Injury and the Glasgow Outcome Scale (GOS) at Discharge 创伤性脑损伤导致的颅内出血概况与出院时格拉斯哥结果量表(GOS)之间的相关性
Pub Date : 2024-01-31 DOI: 10.47363/jnrrr/2024(6)192
Luiz Eduardo Kostin Felipe de Natividade, Carolina Louise Bueno Haurani, Giulia Regina Colaço Bez, Júlia Formes Dias, Letícia Fernandes de Souza Porto
Objectives: To establish a relationship between patient profiles, patterns of intracranial hemorrhage resulting from traumatic brain injury (TBI), and the outcomes measured by GOS. Background: TBI can cause hemorrhages, which exhibit different clinical patterns and imaging findings, typically associated with a worse prognosis. The GOS is an important tool for measuring the functional capacity of post-TBI patients.
目的:确定患者概况、创伤性脑损伤(TBI)导致的颅内出血模式与 GOS 测量结果之间的关系:确定患者概况、创伤性脑损伤(TBI)导致的颅内出血模式与 GOS 测量结果之间的关系。背景:创伤性脑损伤(TBI)可导致出血:创伤性脑损伤可导致出血,出血表现出不同的临床模式和影像学结果,通常预后较差。GOS 是测量创伤性脑损伤后患者功能能力的重要工具。
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引用次数: 0
Roadmap of Portable MRI Implementation in a Northern Canadian Setting - Lessons Learned from the Moose Factory Experience 在加拿大北部地区实施便携式磁共振成像的路线图--从麋鹿工厂的经验中汲取的教训
Pub Date : 2023-12-31 DOI: 10.47363/jnrrr/2023(5)189
Omar Islam, Elaine Innes
1. Review the potential benefits of portable MRI use in a Northern Canadian setting. 2. Describe the challenges of portable MRI implementation in a resource-limited Canadian healthcare environment. 3. Provide guidance to portable MRI implementation at other Canadian and international sites.
1.回顾在加拿大北部环境中使用便携式磁共振成像的潜在好处。2.描述在资源有限的加拿大医疗环境中实施便携式磁共振成像所面临的挑战。3.为在其他加拿大和国际场所实施便携式磁共振成像提供指导。
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引用次数: 0
Medullary and Foraminal Stenosis by Lumbar Vertebral Hemangioma: Case Report 腰椎血管瘤引起的髓腔和椎间孔狭窄:病例报告
Pub Date : 2023-12-31 DOI: 10.47363/jnrrr/2023(5)190
B. Nery, Joaquim Fechine de Alencar Neto, Luis Felipe Ferreira Marques
Vertebral hemangiomas can be defined as benign vascular bone tumors, accounting for only about 3% of spinal tumors. In general, they may demonstrate an asymptomatic clinical presentation, being found accidentally on imaging tests. They have an incidence of about 2.0-27% in the general population and do not require intervention in incidental cases.
椎体血管瘤可定义为良性血管性骨肿瘤,只占脊柱肿瘤的 3%左右。一般来说,它们可能表现为无症状的临床表现,在影像学检查中偶然发现。它们在普通人群中的发病率约为 2.0-27%,偶发病例无需干预。
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引用次数: 0
Open Reproducible Neuroscience Research on Cloud with Infrastructure as Code 利用 "基础设施即代码 "在云上开展开放式可重现神经科学研究
Pub Date : 2023-11-30 DOI: 10.47363/jnrrr/2023(5)188
Suyash Bhogawar, Deepak Singh, Dwith Chenna, M. R. Weginwar
Reproducibility is a key component of scientific research, and its significance has been increasingly recognized in the field of Neuroscience. This paper explores the origin, need, and benefits of reproducibility in Neuroscience research, as well as the current landscape surrounding this practice, and further adds how boundaries of current reproducibility should be expanded to computing infrastructure. The reproducibility movement stems from concerns about the credibility and reliability of scientific findings in various disciplines, including Neuroscience. The need for reproducibility arises from the importance of building a robust knowledge base and ensuring the reliability of research findings. Reproducible studies enable independent verification, reduce the dissemination of false or misleading results, and foster trust and integrity within the scientific community. Collaborative efforts and knowledge sharing are facilitated, leading to accelerated scientific progress and the translation of research into practical applications. On the data front, we have platforms such as openneuro for open data sharing, on the analysis front we have containerized processing pipelines published in public repos which are reusable. There are also platforms such as openneuro, NeuroCAAS, brainlife etc which caters to the need for a computing platform. However, along with benefits these platforms have limitations as only set types of processing pipelines can be run on the data. Also, in the world of data integrity and governance, it may not be far in the future that some countries may require to process the data within the boundaries limiting the usage of the platform. To introduce customized, scalable neuroscience research, alongside open data, containerized analysis open to all, we need a way to deploy cloud infrastructure required for the analysis with templates. These templates are a blueprint of infrastructure required for reproducible research/analysis in a form of code. This will empower anyone to deploy computational infrastructure on cloud and use data processing pipeline on their own infrastructure of their choice and magnitude. Just as docker files are created for any analysis software developed, an IAC template accompanied with any published analysis pipeline, will enable users to deploy infrastructure on cloud required to carry out analysis on their data.
可重复性是科学研究的关键组成部分,其重要性在神经科学领域日益得到认可。本文探讨了神经科学研究中可重复性的起源、需求和益处,以及当前围绕这一实践的情况,并进一步补充了当前可重复性的边界应如何扩展到计算基础设施。可重复性运动源于对包括神经科学在内的各学科科学发现的可信度和可靠性的担忧。对可重复性的需求源于建立强大知识库和确保研究成果可靠性的重要性。可重复性研究能够实现独立验证,减少虚假或误导性结果的传播,促进科学界的信任和诚信。合作努力和知识共享得到促进,从而加快科学进步,并将研究成果转化为实际应用。在数据方面,我们有开放式数据共享平台(如 openneuro);在分析方面,我们有在公共资源库中发布的可重复使用的容器化处理管道。此外,openneuro、NeuroCAAS、brainlife 等平台也满足了对计算平台的需求。不过,这些平台在带来好处的同时也有局限性,因为只能在数据上运行固定类型的处理管道。此外,在数据完整性和管理方面,一些国家可能会要求在限制平台使用的边界内处理数据,这种情况可能不会太远。为了引入定制化、可扩展的神经科学研究,同时向所有人开放数据和容器化分析,我们需要一种方法,利用模板部署分析所需的云基础设施。这些模板是以代码形式呈现的可重现研究/分析所需的基础设施蓝图。这将使任何人都能在云上部署计算基础设施,并根据自己的选择和规模在自己的基础设施上使用数据处理管道。正如为开发的任何分析软件创建 docker 文件一样,IAC 模板与任何已发布的分析管道一起,将使用户能够在云上部署对其数据进行分析所需的基础设施。
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引用次数: 0
Optimization of the Treatment Flow of Neurosurgical Patients with a Glioblastoma using the Enhanced Recovery After Surgery Methodology: A Literature Review 使用 "术后强化恢复 "方法优化神经外科胶质母细胞瘤患者的治疗流程:文献综述
Pub Date : 2023-11-30 DOI: 10.47363/jnrrr/2023(5)186
J. V. Isacker, Wendy Sterckx, Johannes van Loon
Purpose: This study aims to create an elaborated version of the Enhanced Recovery After Surgery methodology, specifically applied to neurosurgical patients with a glioblastoma. Introduction: Being diagnosed with a glioblastoma is a terminal diagnosis with a median survival rate of 14,6 months. The introduction of an Enhanced Recovery After Surgery can provide a solution for current challenges such as the under-pressure health care system because of a lack of nurses and welltrained nurses in neurosurgical problems. Enhanced Recovery After Surgery benefits the patient, healthcare teams and society. Methods: A literature review with two different search strategies was conducted. First, the needs and expectations of patients with a glioblastoma were identified. Seventy-five papers from four databases, PubMed, Embase, CINAHL and Cochrane Library, were eligible. Fourteen papers were included in this study. Second, the existing Enhanced Recovery After Surgery protocols were examined. A total of 3,521 papers were screened by two independent researchers, of which 82 met the inclusion criteria and 50 were determined relevant for this study. In this way, an elaborated version of the Enhanced Recovery After Surgery methodology based on the needs of patients with a glioblastoma is created. Results: Patients with a glioblastoma may face numerous needs. Due to a poor diagnosis and uncertain future, they could feel distressed and anxious. Patients expect more information, support and availability from health professionals. Therefore, it is important for healthcare professionals to make sure that patients do not lose all hope after the diagnosis because losing hope is associated with depression and a poorer quality of life. All these needs were integrated in the Enhanced Recovery After Surgery protocol and combined with new insights from the literature. The first bundle of recommendations in the Enhanced Recovery After Surgery for patients with a glioblastoma belongs to the preoperative phase and includes: information and education, prehabilitation, nutrition support and fasting time, alcohol and smoking, comorbidities and medication. The intraoperative phase includes advice about antibiotics, body temperature, craniotomy, stitches and extubating. Finally, the postoperative phase includes recommendations regarding thromboembolism, nausea and vomiting, analgesics, oral nutrition, fluids, invasive lines, mobilization, urinary catheter, drains, discharge, telephone follow-up and social and emotional support. Conclusion: The established protocol needs to be constantly adapted to new evidence. Only with an appropriate multidisciplinary collaboration and thoughtful introduction of the Enhanced Recovery After Surgery, the implementation and sustainability of the new Enhanced Recovery After Surgery protocol will succeed in daily practice.
目的:本研究旨在创建一个精心设计的 "术后强化康复 "方法版本,特别适用于神经外科胶质母细胞瘤患者。简介胶质母细胞瘤是一种绝症,中位生存期仅为 14.6 个月。由于缺乏护士和训练有素的护士来解决神经外科问题,医疗保健系统压力过大。加强术后恢复有利于患者、医疗团队和社会。方法:采用两种不同的搜索策略进行文献综述。首先,确定了胶质母细胞瘤患者的需求和期望。来自 PubMed、Embase、CINAHL 和 Cochrane Library 四个数据库的 75 篇论文符合条件。本研究共收录了 14 篇论文。其次,研究了现有的术后强化恢复方案。两名独立研究人员共筛选了 3521 篇论文,其中 82 篇符合纳入标准,50 篇被确定与本研究相关。通过这种方式,根据胶质母细胞瘤患者的需求,创建了精心设计的 "术后强化康复 "方法。研究结果胶质母细胞瘤患者可能面临众多需求。由于诊断不准确和未来不确定,他们可能会感到痛苦和焦虑。患者希望从医护人员那里获得更多的信息、支持和服务。因此,医护人员必须确保患者在确诊后不会失去所有希望,因为失去希望会导致抑郁和生活质量下降。所有这些需求都被纳入了 "术后恢复强化方案",并与文献中的新见解相结合。针对胶质母细胞瘤患者的 "术后强化康复 "中的第一组建议属于术前阶段,包括:信息和教育、术前康复、营养支持和禁食时间、饮酒和吸烟、合并症和药物治疗。术中阶段包括有关抗生素、体温、开颅手术、缝合和拔管的建议。最后,术后阶段包括有关血栓栓塞、恶心和呕吐、镇痛药、口服营养、输液、侵入性管路、移动、导尿、引流、出院、电话随访以及社会和情感支持的建议。结论需要根据新证据不断调整既定方案。只有通过适当的多学科合作,并深思熟虑地引入 "术后强化恢复",新的 "术后强化恢复 "方案的实施和可持续性才能在日常实践中取得成功。
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引用次数: 0
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Journal of Neurology Research Reviews & Reports
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