Development of Resorb-able Nano Composite Films for Orthodontic Applications

Farhana Hasham, M. Mujahid
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Abstract

First generation membranes developed were non-resorbable and required a second surgical procedure for their removal. In order to overcome this obstacle biodegradable, resorb-able composite films were developed which may also assist in bone healing. In this paper, composite films comprising varying amounts of nano hydroxyapatite (0.5-30%) in chitosan (biopolymer) matrix were prepared by solvent casting method. Composite films were further characterized and mechanical properties were evaluated. Results showed increased strength and stability until 10-wt% HA beyond which properties declined. Immersion of composite films in SBF solution confirmed their bioactivity. This study concludes composite films with 10-wt% HA as a potential candidate for barrier films in the field of orthopedics and dentistry.
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正畸用可吸收纳米复合膜的研制
第一代膜是不可吸收的,需要第二次手术才能去除。为了克服这一障碍,生物可降解、可吸收的复合膜被开发出来,它也可能有助于骨愈合。以壳聚糖(生物聚合物)为基体,采用溶剂浇铸法制备了不同含量的纳米羟基磷灰石(0.5 ~ 30%)复合膜。对复合膜进行了进一步表征,并对其力学性能进行了评价。结果表明,在10-wt% HA之前,强度和稳定性都有所增加,超过这一比例,性能就会下降。复合膜浸泡在SBF溶液中证实了其生物活性。本研究认为含10-wt%透明质酸的复合膜是骨科和牙科领域屏障膜的潜在候选材料。
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