Mixed type plasmacytoma with multiple myeloma: therapy and prognosis

Abstract

Extramedullary and paraskeletal plasmacytomas are not common and are usually one of the possible complications of multiple myeloma. This variant of the disease is more aggressive, less responsive to therapy, and recurs more often than conventional multiple myeloma. In our work, we described two cases of aggressively ongoing multiple myeloma with a mixed plasmacytic variant diagnosed at the time of setting the diagnosis. In both cases, a rapid progressive course was observed despite the wide range of both the newest drugs and the classical chemotherapy drugs used during treatment. Thus, this variant of the disease remains most often resistant to the therapy, with an unfavorable prognosis, and requires further study and improvement of the treatment approach to improve outcomes.