{"title":"Primary pulmonary NUT midline carcinoma and its diagnostic challenges: A case report","authors":"Dominic Ong, Usha Ganugapati","doi":"10.18231/j.ijpo.2022.085","DOIUrl":null,"url":null,"abstract":"NUT midline carcinoma (NMC) is a rare and aggressive cancer genetically characterized by a chromosomal rearrangement of the NUT gene. Primary pulmonary NMC is even more rare. NMC typically presents with histological features of a poorly differentiated squamous cell carcinoma. We report a case of a 23-year-old female patient with NMC in the lung and pleura presented to a midsize, midwestern Canadian hospital. This article emphasizes the diagnostic challenges posed by NMC and highlights an encounter with this aggressive cancer, which had not previously been diagnosed in our health region.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"79 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Pathology and Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18231/j.ijpo.2022.085","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
NUT midline carcinoma (NMC) is a rare and aggressive cancer genetically characterized by a chromosomal rearrangement of the NUT gene. Primary pulmonary NMC is even more rare. NMC typically presents with histological features of a poorly differentiated squamous cell carcinoma. We report a case of a 23-year-old female patient with NMC in the lung and pleura presented to a midsize, midwestern Canadian hospital. This article emphasizes the diagnostic challenges posed by NMC and highlights an encounter with this aggressive cancer, which had not previously been diagnosed in our health region.
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