Self-powered liquid volume sensor aiming at lab-on-chip applications

2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2016-04-17 DOI:10.1109/NEMS.2016.7758194

Hao Wang, Tao Wang, Chengkuo Lee

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Abstract

Technology for enabling drug delivery with precise control is strongly demanded by patients with diabetes or other chronic diseases. More intelligent functions such as drug loading and delivery in controllable manner without requiring electrical power will make low-cost drug delivery patches come true. One of the promising candidates is triboelectric technology which has been deployed as nanogenerators and self-powered glucose sensors recently. In this paper, the drug delivery is triggered by finger-pressing on a polymer based micropump. Considering that the finger-pressing should be an action of very low frequency, e.g., 1 to 2 Hz, triboelectric energy harvester (TEH) based on contact-separation mode between patterned biocompatible polymer layer and Aluminum (Al) film is integrated with microneedles on a flexible skin patch. Leveraging triboelectric materials and compatible fabrication technology, we successfully develop a self-powered flexible skin patch for transdermal insulin delivery with novel liquid volume sensor to monitor delivered drug volume.

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面向芯片上实验室应用的自供电液体体积传感器

糖尿病或其他慢性疾病患者迫切需要精确控制给药的技术。更多的智能功能，如不需要电力的可控方式的药物装载和递送，将使低成本的药物递送贴片成为现实。摩擦电技术是一个很有前途的候选技术，它最近被应用于纳米发电机和自供电葡萄糖传感器。在本文中，通过手指按压基于聚合物的微泵来触发药物输送。考虑到手指按压应该是一个非常低频率的动作，例如1到2hz，基于图案化生物相容性聚合物层和铝(Al)膜之间的接触分离模式的摩擦电能量收集器(TEH)与微针集成在柔性皮肤贴片上。利用摩擦电材料和兼容的制造技术，我们成功地开发了一种自供电的柔性皮肤贴片，用于经皮胰岛素输送，该贴片具有新颖的液体体积传感器，可以监测输送的药物体积。

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2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

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