ANALYSIS AND EVALUATION OF BLOOD PLASMA PROTEOMIC PROFILE VIOLATIONS DUE TO THE INCREASED CONCENTRATION OF FLUORIDE ION IN CHILDREN’S URINE

Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-07-01 DOI:10.35627/2219-5238/2019-316-7-23-26

N. Zaitseva, M. Zemlianova, N. Bulatova, J. V. Koldibekova

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引用次数: 5

Abstract

We evaluated the air quality by the content of fluorine-containing compounds according to monitoring studies, chemical and analytical determination of fluoride ion in urine and performed proteomic analysis of blood plasma in children of the observation and comparison group. The increased content of fluoride ion in the urine was found in children of the observation group relative to the same indicator in children of the comparison group and the reference level in conditions of poor air quality for the hydrofluoride content due to the economic activity of aluminum production facilities. The concentration of fluoride ion in the urine is justified as a marker of inhalation exposure. A comparative analysis revealed the presence of significant differences in the relative volume of protein spots. Mass spectra were obtained that contain information about the peptides included in the composition of the studied protein set and the genes encoding identifiable proteins were established.

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儿童尿液中氟离子浓度升高对血浆蛋白质组谱影响的分析与评价

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