Review of the Ubiquitin Role in DNA Repair and Tumorigenesis, with Emphasis in Breast Cancer Treatment; Current Data and Future Options

Ubiquitination Governing DNA Repair - Implications in Health and Disease Pub Date : 2018-08-01 DOI:10.5772/INTECHOPEN.72600

Despoina Mourtzoukou, I. Drikos, N. Goutas, D. Vlachodimitropoulos

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引用次数: 4

Abstract

Breast carcinoma remains the commonest carcinoma among women worldwide. Despite the fact that impressive progression has been achieved so far regarding pathophysiol-ogy, histopathology and treatment of this cancer, there are still undiscovered fields on molecular and therapeutic levels. The need of resolving problems such as chemoresistance, recurrence and metastasis has led in revealing key molecules in the development and progression of malignancies, including breast tumors. In this review, we will briefly describe the functions of ubiquitin and post-translational modifications (PTMs) focusing specially in DNA repair and then discuss about the implication of ubiquitin and related molecules in tumorigenesis and specifically in breast carcinoma. So far there are only few drugs approved by FDA that target the ubiquitin system. There will be an analysis regarding the current and potential anti-cancer therapeutic strategies based on targeting specific ubiquitin-related molecules.

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泛素在DNA修复和肿瘤发生中的作用，重点是乳腺癌治疗当前数据和未来选项

乳腺癌仍然是全世界妇女中最常见的癌症。尽管到目前为止，关于这种癌症的病理生理学、组织病理学和治疗已经取得了令人印象深刻的进展，但在分子和治疗水平上仍有未发现的领域。解决诸如化疗耐药、复发和转移等问题的需要导致揭示恶性肿瘤(包括乳腺肿瘤)发生和进展的关键分子。在这篇综述中，我们将简要介绍泛素和翻译后修饰(PTMs)的功能，特别是在DNA修复中，然后讨论泛素和相关分子在肿瘤发生特别是乳腺癌中的意义。到目前为止，FDA批准的针对泛素系统的药物很少。将分析目前和潜在的基于靶向特定泛素相关分子的抗癌治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ubiquitination Governing DNA Repair - Implications in Health and Disease

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