Nanofluidics for cell and drug delivery

Abstract

Management of chronic pathologies requires the development of novel strategies for the delivery of drugs and cell therapies, ad hoc. We have developed implantable micronanofluidic-based platforms that leverage molecular nanoconfinement for the controlled administration of drugs and transplantation of cells. These rely on silicon nanofabricated membranes and 3D-printed polymeric architectures that afford long term function in vivo without complex pumping mechanisms or actuation. In this work, we present our recent advances in zero-order drug delivery implants, remotely tunable delivery devices, and subcutaneous encapsulations for endocrine cells transplantation.