Mueller-matrix microscopy of laser-induced monochromatic fluorescent fields of preparations of human internal organs and histological diagnostics of the time of age of damage formation

International Conference on Correlation Optics Pub Date : 2021-12-21 DOI:10.1117/12.2616667

A. Litvinenko, D. Kvasnyuk, A. Y. Vanchulyak, M. Stashkevich, A. Motrich, A. Y. Mikhailova, M. P. Gorskiy, M. Slyotov

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Abstract

The article contains the results of experimental testing of methods of azimuthal-invariant Mueller-matrix microscopy (Mueller-matrix invariants - MMI) of optically anisotropic fluorophores of samples of histological sections of the brain, liver and kidney, as well as myocardium and lung tissue; temporal detection of variations in the magnitude of the statistical moments of the 1st - 4th orders, characterizing the distributions of the MMI value of linear birefringence and optical activity of samples of histological sections of the brain, liver and kidney, as well as myocardium and lung tissue with different age of damage; determination of the diagnostic efficiency (time interval and accuracy) of establishing the age of damage to human internal organs by digital histological methods of MMI mapping of optical anisotropy of fluorophores in histological sections of the brain, liver and kidney, as well as myocardium and lung tissue.

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米勒基质显微镜下激光诱导单色荧光场对人体内脏器官的制备及年龄损伤形成的组织学诊断

本文介绍了对脑、肝、肾、心肌和肺组织的组织学切片样品的光学各向异性荧光团的方位不变穆勒矩阵显微镜(Mueller-matrix invariants - MMI)方法的实验测试结果;时间检测1 - 4阶统计矩量的变化，表征脑、肝、肾以及不同损伤年龄的心肌和肺组织的组织学切片样品的线性双折射MMI值和光学活性的分布;测定脑、肝、肾、心肌和肺组织组织切片荧光团光学各向异性的MMI数字组织学方法建立人体内脏器官损伤年龄的诊断效率(时间间隔和准确性)。

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International Conference on Correlation Optics

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