Photovoltaic restoration of high visual acuity in rats with retinal degeneration

2015 7th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2015-04-22 DOI:10.1109/NER.2015.7146606

H. Lorach, Georges A. Goetz, Y. Mandel, R. Smith, David Boinagrov, X. Lei, R. Dalal, P. Huie, T. Kamins, J. Harris, K. Mathieson, A. Sher, D. Palanker

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Abstract

Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We developed subretinal photovoltaic arrays to convert pulsed light into bi-phasic pulses of current to stimulate the nearby inner retinal neurons. Bright pulsed illumination is provided by image projection from video goggles and avoids photophobic effects by using near-infrared (NIR, 880-915nm) light. Experiments in-vitro and in-vivo demonstrate that the network-mediated retinal stimulation preserves many features of natural vision, such as flicker fusion, adaptation to static images, and most importantly, high spatial resolution. Our implants with 70μm pixels restored visual acuity to half of the normal level in rats with retinal degeneration. Ease of implantation and tiling of these wireless arrays to cover a large visual field, combined with their high resolution opens the door to highly functional restoration of sight.

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视网膜变性大鼠高视力的光电恢复

视网膜变性患者由于光感受器的逐渐消亡而丧失视力。电刺激残存的视网膜神经元为传递视觉信息提供了另一种途径。我们开发了视网膜下光伏阵列，将脉冲光转换为双相脉冲电流，以刺激附近的视网膜内神经元。明亮的脉冲照明由视频护目镜的图像投影提供，并通过使用近红外(NIR, 880-915nm)光避免恐光效应。体外和体内实验表明，网络介导的视网膜刺激保留了自然视觉的许多特征，如闪烁融合、对静态图像的适应，以及最重要的高空间分辨率。我们的70μm像素植入物使视网膜变性大鼠的视力恢复到正常水平的一半。这些无线阵列易于植入和平铺以覆盖大视野，再加上它们的高分辨率，为高度功能性的视力恢复打开了大门。

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2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)

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