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2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)最新文献

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Computationally efficient, configurable, causal, real-time phase detection applied to local field potential oscillations 计算效率高,可配置,因果,实时相位检测应用于局部场电位振荡
Pub Date : 2015-07-02 DOI: 10.1109/NER.2015.7146781
Jadin C. Jackson, Rob Corey, Greg Loxtercamp, S. Stanslaski, Heather Orser, T. Denison
Neurological implantable devices with electrophysiological sensing capabilities may enable new medical therapies and diagnostics. Of specific interest is phase-dependent delivery of therapy-such as electrical stimulation-as a potential method to enhance therapy effectiveness in improving diseased or damaged physiological processes with respect to rhythmic biomarkers, while minimizing the average energy required to deliver the therapy. To address this need for phase-detection, within the constraints of device power limits, we have developed a computationally efficient, causal, real-time Fourier transform (RTFT) for use as a phase detection method that is both general and highly configurable. The application of this method to theta-band local field potentials recorded from the brains of sheep is demonstrated.
具有电生理传感能力的神经系统植入式装置可以实现新的医学治疗和诊断。我们特别感兴趣的是相依赖的治疗递送——比如电刺激——作为一种潜在的方法,可以提高治疗效果,改善患病或受损的生理过程,与节律性生物标志物相关,同时最小化递送治疗所需的平均能量。为了解决这种相位检测的需求,在设备功率限制的约束下,我们开发了一种计算效率高、因果关系好、实时的傅立叶变换(RTFT),作为一种通用且高度可配置的相位检测方法。证明了该方法在羊脑的θ波段局部场电位记录中的应用。
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引用次数: 3
Correlation between cortical inhibition and auditory stream segregation in a driving environment 驾驶环境中皮层抑制与听觉流分离的关系
Pub Date : 2015-07-02 DOI: 10.1109/NER.2015.7146731
E. Gonzalez-Trejo, Manuel C. Kohl, Alexander Steinbach, Hannes Mögele, Norbert Pfleger, D. Strauss
Streams of information reach the brain in different modalities while driving (both from the vehicle user interface as well as the environment), each requiring a certain degree of attention from the driver. The driver should ideally be able to focus on the road ahead and not on secondary streams such as vehicle alerts, mobile phone, passengers or radio. However, the individual ability to selectively ignore distractions can have a direct influence on driving performance. Here, we use paired-chirp auditory late responses (ALRs) in order to assess long interval cortical inhibition (LICI) in healthy subjects, and compare it to the score in an auditory stream segregation task within a driving simulator. Results show significant correlation between LICI and task scores, suggesting that people with a higher/more effective cortical inhibition as measured by ALRs can ignore distracting streams easily, while people with less effective cortical inhibition find harder to concentrate on a single, more relevant stream. The fundamental results obtained suggest that cortical inhibition may be employed as a predictor of driving performance, useful for the design of auditory human-vehicle interfaces.
在驾驶过程中,信息流以不同的方式到达大脑(包括来自车辆用户界面和环境的信息),每一种信息都需要驾驶员一定程度的注意力。理想情况下,司机应该能够专注于前方的道路,而不是次要流,如车辆警报、手机、乘客或收音机。然而,个人选择性忽略干扰的能力会对驾驶表现产生直接影响。在这里,我们使用配对啁啾听觉延迟反应(ALRs)来评估健康受试者的长间隔皮层抑制(LICI),并将其与驾驶模拟器中听觉流分离任务的得分进行比较。结果显示,LICI与任务得分之间存在显著的相关性,表明alr测量的皮质抑制较高/更有效的人可以很容易地忽略分散注意力的流,而皮质抑制较低的人则很难集中注意力于单一的、更相关的流。获得的基本结果表明,皮质抑制可以作为驾驶性能的预测因子,对听觉人车界面的设计有用。
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引用次数: 0
A hybrid NMES-exoskeleton for real objects interaction 用于真实物体交互的混合nmes -外骨骼
Pub Date : 2015-07-02 DOI: 10.1109/NER.2015.7146710
A. Crema, M. Mancuso, A. Frisoli, F. Salsedo, F. Raschellà, S. Micera
Clinicians constantly face the need to rehabilitate stroke patients to re-establish coordinate reach and grasp. Rehabilitation, to be effective, requires intensive and repetitive tasks. Assist-as-needed motion control for reach and grasp assistance are usually treated separately, and mostly based on virtual reality games. To increase the clinical outcome, we designed flexible modules for a clinical platform, able to provide synchronous reach and grasp support and to interact with common objects. An upper limb exoskeleton provides the reaching support, a NMES-system based on electrode arrays provides grasp control by means of muscle contraction, and a satellite robot presents the objects to be grasped. Specific rehabilitation tasks can be implemented by taking advantage of the possibility to quantify the support needed by patients, and to modulate both the mechanical and NMES support over the reachable workspace.
临床医生不断面临脑卒中患者康复需要重新建立协调的触及和把握。康复要想有效,需要密集和重复的工作。触手和抓取辅助的按需运动控制通常是分开处理的,而且大多是基于虚拟现实游戏。为了提高临床效果,我们为临床平台设计了灵活的模块,能够提供同步伸手和抓握支持,并与常见物体进行交互。上肢外骨骼提供伸展支撑,基于电极阵列的nmes系统通过肌肉收缩提供抓取控制,卫星机器人展示要抓取的物体。具体的康复任务可以通过利用量化患者所需支持的可能性来实施,并在可到达的工作空间内调节机械和NMES支持。
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引用次数: 5
Computational studies on urinary bladder smooth muscle: Modeling ion channels and their role in generating electrical activity 膀胱平滑肌的计算研究:模拟离子通道及其在产生电活动中的作用
Pub Date : 2015-07-02 DOI: 10.1016/J.BPJ.2014.11.3204
C. Mahapatra, K. Brain, R. Manchanda
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引用次数: 8
A low-cost, 61-channel µECoG array for use in rodents 用于啮齿类动物的低成本,61通道微ECoG阵列
Pub Date : 2015-07-02 DOI: 10.1109/NER.2015.7146687
V. Woods, Charles Wang, S. Bossi, Michele N. Insanally, M. Trumpis, R. Froemke, J. Viventi
Micro-Electrocorticography (μECoG) offers a minimally invasive, high resolution interface with large areas of cortex. A wide variety of μECoG designs have been developed and customized [1]-[4], including active, multiplexed arrays [5] and arrays on dissolving substrates for increased conformal contact [6]. However, designing and fabricating customized μECoG arrays requires access to microfabrication facilities, which many neuroscience labs do not have. Microfabrication is also typically labor intensive and expensive. Commercial μECoG arrays with 64 electrodes and coarser dimensions cost approximately $1000, limiting their suitability for chronic implantation in large numbers of animals. Here we present a high density (406 μm spacing), flexible (~30 μm thin), 61-contact μECoG electrode array fabricated using a low-cost, commercial manufacturing process. The array costs just $26 when ordered in quantities of 100, with the cost per electrode increasing slightly when lower quantities are ordered. Fine pitch wires minimize the size of the interconnections, enabling chronic implantation in rodents. In-house post-processing of the fabricated μECoG arrays added optional electrode coatings, such as platinum black, to reduce the electrode impedance. Our electrode design and manufacturing process dramatically improves the accessibility and reduces the cost of high-volume, high-resolution neuroscience.
微皮质电图(μECoG)提供了一个具有大面积皮质的微创、高分辨率界面。各种各样的μECoG设计已经开发和定制[1]-[4],包括有源,多路复用阵列[5]和溶解基板上的阵列,以增加保形接触[6]。然而,设计和制造定制的μECoG阵列需要使用微加工设备,这是许多神经科学实验室所没有的。微加工也是典型的劳动密集型和昂贵的。商业μECoG阵列具有64个电极和更粗的尺寸,成本约为1000美元,限制了它们对大量动物慢性植入的适用性。在这里,我们提出了一种高密度(406 μm间距),柔性(~30 μm薄),61触点μECoG电极阵列,采用低成本的商业制造工艺制造。当订购数量为100个时,该阵列的成本仅为26美元,当订购数量较少时,每个电极的成本略有增加。细间距导线使连接的尺寸最小化,使啮齿类动物能够长期植入。制备的μECoG阵列的内部后处理添加了可选的电极涂层,如铂黑,以降低电极阻抗。我们的电极设计和制造工艺大大提高了高容量,高分辨率神经科学的可及性并降低了成本。
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引用次数: 9
Fast calibration of a thirteen-command BCI by simulating SSVEPs from trains of transient VEPs - towards time-domain SSVEP BCI paradigms 从瞬态vep序列向时域SSVEP BCI范式模拟SSVEP的13指令BCI快速定标
Pub Date : 2015-07-02 DOI: 10.1109/NER.2015.7146591
M. A. Abbasi, A. Gaume, N. Francis, G. Dreyfus, F. Vialatte
A 13-command Brain-Computer Interface (BCI) based on Steady-State Visual Evoked Potentials (SSVEP) is assessed. The SSVEPs are simulated from VEP sequences recorded by electroencephalography (EEG) on the same subjects. SSVEP features extracted in the time domain are averaged over all channels of the occipital region. Most subjects achieved satisfactory classification rate (50~80% correct command detection). A simulated/offline information transfer rate of 60 bits/min is achieved, averaged across the best eight subjects. Online validation was performed on one new independent subject. The calibration procedure, based on VEP recordings, lasts one minute whatever the number of commands. Online information transfer rate of 58 bits/min is achieved.
对基于稳态视觉诱发电位(SSVEP)的13指令脑机接口(BCI)进行了评估。ssvep是根据同一受试者的脑电图记录的VEP序列来模拟的。在时域中提取的SSVEP特征在枕区所有通道上进行平均。大多数受试者的分类率满意(命令正确率为50~80%)。模拟/离线的信息传输速率达到60比特/分钟,在最好的8个科目中平均。在一个新的独立受试者上进行在线验证。校准过程,基于VEP记录,持续一分钟,无论命令的数量。在线信息传输速率可达58位/分。
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引用次数: 4
Modulated high frequency oscillations can identify regions of interest in human iEEG using hidden Markov models 调制高频振荡可以利用隐马尔可夫模型识别人类脑电图感兴趣的区域
Pub Date : 2015-07-02 DOI: 10.1109/NER.2015.7146777
Mirna Guirgis, Y. Chinvarun, M. D. Campo, P. Carlen, B. Bardakjian
This study investigated the seizure and non-seizure state transitions in the intracranial electroencephalogram (iEEG) recordings of extratemporal lobe epilepsy patients. Cross-frequency coupling between low and high frequency oscillations in conjunction with an unsupervised learning algorithm - namely, hidden Markov models - was used to objectively identify seizure and non-seizure states as well as transition states. Channels consistently capturing two and/or three distinct states in a 32-channel iEEG array were able to identify regions of interest located in resected tissue of patients who experienced improved post-surgical outcomes.
本研究探讨了颞外叶癫痫患者的颅内脑电图(iEEG)记录中癫痫发作和非癫痫状态的转变。低频和高频振荡之间的交叉频率耦合与无监督学习算法(即隐马尔可夫模型)相结合,用于客观地识别癫痫发作和非癫痫发作状态以及过渡状态。在32通道iEEG阵列中,通道持续捕获两个和/或三个不同的状态,能够识别位于切除组织中的感兴趣区域,这些患者经历了改善的术后预后。
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引用次数: 6
iNODE in-vivo testing for selective vagus nerve recording and stimulation 选择性迷走神经记录和刺激的iNODE体内试验
Pub Date : 2015-07-02 DOI: 10.1109/NER.2015.7146675
Oscar F. Cota, Mario Schlösser, M. Schiek, T. Stieglitz, M. Gierthmuehlen, D. Plachta
Hypertension is a wide spread disease and despite pharmacological treatment some patients cannot obtain any relief from medication. In previous work, we could show that blood pressure can be reduced by Vagus Nerve Stimulation (VNS) almost free from side effects. In this work, we focus on the implementation of a miniaturized system using a modified embedded sensor/actuator device iNODE for vagus nerve recording and stimulation. The results illustrate that this device, using a 3.3 V power supply, 58.9 mW while stimulating, 7.8 mW while recording, is capable of reducing the blood pressure, showing equivalent results to major laboratory equipment.
高血压是一种广泛传播的疾病,尽管药物治疗,一些患者不能从药物中获得任何缓解。在之前的工作中,我们可以证明迷走神经刺激(VNS)可以降低血压,几乎没有副作用。在这项工作中,我们专注于使用改进的嵌入式传感器/执行器设备iNODE实现迷走神经记录和刺激的小型化系统。结果表明,该装置使用3.3 V电源,刺激时58.9 mW,记录时7.8 mW,能够降低血压,显示出与主要实验室设备相当的结果。
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引用次数: 1
Cortical Activity waves are the physical carriers of memory and thought 皮层活动波是记忆和思维的物理载体
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146635
P. Koch, Gerry Leisman
Growing and propagating waves of neural activity are the natural resonant modes of synaptic energy. In a layered geometry typifying the mammalian cortex, a time delay (T) in inter-layer signals effectively controls the temporal and spatial frequencies of the waves. As a function of T, two very different types of wave can grow from ubiquitous noise. One is coherent, and its resonant spatial frequency increases with increasing T. However, further increase eventually leads to a discontinuous increase in both wavelength and temporal frequency. The result is a region of T values wherein two waves grow simultaneously and interfere in random fashion. This remarkable duality, whose origin is in the phase relations of the amplified waves, leads us to propose that coherent waves are instrumental in the retrieval of memory and random waves embody original thought.
神经活动的生长和传播波是突触能量的自然共振模式。在哺乳动物皮层的分层几何中,层间信号的时间延迟(T)有效地控制了波的时间和空间频率。作为T的函数,两种截然不同的波可以从无处不在的噪声中产生。一种是相干的,其共振空间频率随t的增加而增加,但进一步增加最终导致波长和时间频率的不连续增加。结果是一个T值区域,其中两个波同时增长并以随机方式干涉。这种显著的二象性,其起源是放大波的相位关系,使我们提出相干波有助于记忆的检索,而随机波体现了原始思想。
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引用次数: 3
A versatile fast-development platform applied to closed-loop diaphragmatic pacing 应用于闭环膈肌起搏的多功能快速开发平台
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146742
A. Zbrzeski, Ricardo Siu, Y. Bornat, B. Hillen, R. Jung, S. Renaud
People with cervical spinal cord injury have partial or complete loss of ventilatory control and require ventilator assist. Open-loop diaphragmatic pacing can be utilized to provide this assist. A closed-loop diaphragmatic pacing system could overcome the drawbacks for manual titration of the stimulation and respond to changing ventilatory requirements. We have developed a versatile custom hardware platform dubbed “Multimed” for biosignal acquisition and parallel real-time computation, data display and storage. We have also developed a new rodent model for diaphragmatic pacing. Using these we illustrate, to our knowledge for the first-time, the successful ability to perform respiratory flow-phase triggered closed-loop diaphragmatic stimulation with resultant changes in respiratory flow and tidal volume.
颈脊髓损伤患者部分或完全丧失通气控制,需要呼吸机辅助。开环膈起搏可以提供这种辅助。闭环膈肌起搏系统可以克服手动滴定刺激的缺点,并对不断变化的通气需求做出反应。我们开发了一个多功能定制硬件平台,称为“multitimed”,用于生物信号采集和并行实时计算,数据显示和存储。我们还开发了一种新的啮齿动物膈肌起搏模型。据我们所知,利用这些方法,我们首次成功地展示了呼吸流相触发的闭环膈肌刺激的能力,并由此改变了呼吸流和潮气量。
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引用次数: 6
期刊
2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)
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