Omid Ghadami, Hongyu Lu, Matthew R. Chan, Mila Tan, Saeromi Chung, Sang Heon Lee, Matthew T. Holden, Ryan de Ridder, Barry Merriman, D. Hall
{"title":"Helix: An Electrochemical CMOS DNA Synthesizer","authors":"Omid Ghadami, Hongyu Lu, Matthew R. Chan, Mila Tan, Saeromi Chung, Sang Heon Lee, Matthew T. Holden, Ryan de Ridder, Barry Merriman, D. Hall","doi":"10.1109/vlsitechnologyandcir46769.2022.9830446","DOIUrl":null,"url":null,"abstract":"This work describes the highest feature density CMOS-based DNA synthesizer, where individually addressable sub-μm pixels generate acid in situ for deprotection. A new redox chemistry enables this at low voltages. Implemented in 65nm CMOS, electrodes as small as 0.6μm2 were implemented, and oligos up to 100 nucleotides (nt) were synthesized.","PeriodicalId":332454,"journal":{"name":"2022 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2022 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/vlsitechnologyandcir46769.2022.9830446","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
This work describes the highest feature density CMOS-based DNA synthesizer, where individually addressable sub-μm pixels generate acid in situ for deprotection. A new redox chemistry enables this at low voltages. Implemented in 65nm CMOS, electrodes as small as 0.6μm2 were implemented, and oligos up to 100 nucleotides (nt) were synthesized.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
