Glukhareva Ae, Afonin Gv, Mel'nikova Aa, Grivtsova Ly, Kolobaev Iv, Ivanov Sa, Kaprin Ad
{"title":"The Role of the NETosis Phenomena as a Function of Neutrophils in the Pathogenesis of Infection and Cancer","authors":"Glukhareva Ae, Afonin Gv, Mel'nikova Aa, Grivtsova Ly, Kolobaev Iv, Ivanov Sa, Kaprin Ad","doi":"10.26420/austinjinfectdis.2022.1074","DOIUrl":null,"url":null,"abstract":"Neutrophils are one of the key barriers to anti-infective protection, an important mechanism of which is NETosis - the formation of neutrophil extracellular traps (NET). In recent years, this ambiguous biological phenomenon has been considered as a factor of unfavorable prognosis in some types of cancer. This review is devoted to the analysis of the role of NETosis in the pathogenesis of autoimmune diseases and other non-communicable diseases. The role of NET in malignant tumors, in particular in metastasis and progression of the tumor process, has been studied and data on the subpopulations of neutrophils – low-density neutrophils (LDN) and high-density neutrophils (HDN) in tumor processes have been analyzed. Further study of the phenomenon of netosis and the characteristics of peripheral blood neutrophils in cancer patients will be useful both for detailing the mechanisms of the metastatic cascade and for identifying their role as a biomarker and a possible therapeutic target.","PeriodicalId":346223,"journal":{"name":"Austin Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Austin Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26420/austinjinfectdis.2022.1074","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Neutrophils are one of the key barriers to anti-infective protection, an important mechanism of which is NETosis - the formation of neutrophil extracellular traps (NET). In recent years, this ambiguous biological phenomenon has been considered as a factor of unfavorable prognosis in some types of cancer. This review is devoted to the analysis of the role of NETosis in the pathogenesis of autoimmune diseases and other non-communicable diseases. The role of NET in malignant tumors, in particular in metastasis and progression of the tumor process, has been studied and data on the subpopulations of neutrophils – low-density neutrophils (LDN) and high-density neutrophils (HDN) in tumor processes have been analyzed. Further study of the phenomenon of netosis and the characteristics of peripheral blood neutrophils in cancer patients will be useful both for detailing the mechanisms of the metastatic cascade and for identifying their role as a biomarker and a possible therapeutic target.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
