A Review on Formulation and Evaluation Approaches for Fast Release Tablet

P. Upadhyay, K. ., P. Chaudhary, S. Upadhyay
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Abstract

Among all forms of volume, the tablet is the most popular volume method available today due to its convenience of self-control, coherence and easy production; sometimes immediate relief the onset of action is necessary than conventional treatment in most cases. To overcome these barriers, a form of immediate release dose has emerged like other oral dose forms. Forms of rapid drug release dispersal immediately after treatment with an improved degree of elimination. The basic method used in pill development is the use of superdisintegrants such as Kyron T-314 based on polymer bonded Polycarboxylic acid per USP/NF and has a K+ionic form. The Kyron T-316 is a relatively new fast disintegration system specifically for acid-containing drugs that promote dispersion and dissolution. Sodium starch glycolate (Primogel, Explotab), carboxymethyl cellulose (Croscarmellose) etc. The drug categories selected for immediate release are painkillers and anti-inflammatory drugs such as Ibuprofen, Diclofenac sodium. Anti-coagulants such as Dicoumarol, Dipyridamol. Anti-Depressants like Amoxapiine. Antidiabetic as Glipizide. Antibacterial like Linezolid, antihypertensive drugs like Amlodipine, Minoxidil, Nifedipine are best for immediate release
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快速缓释片的处方及评价方法综述
在所有形式的卷法中,片剂是当今最受欢迎的卷法,因为它便于自我控制、连贯和易于生产;在大多数情况下,立即采取行动比常规治疗更有必要。为了克服这些障碍,出现了一种像其他口服剂型一样的立即释放剂型。药物快速释放的形式在治疗后立即分散,消除程度提高。在药片开发中使用的基本方法是使用超级崩解剂,如Kyron T-314,它基于聚合物结合的聚羧酸,符合USP/NF,具有K+离子形式。Kyron T-316是一种相对较新的快速分解系统,专门用于促进分散和溶解的含酸药物。乙醇酸淀粉钠(Primogel, Explotab),羧甲基纤维素(Croscarmellose)等。选择立即释放的药物类别是止痛药和消炎药,如布洛芬、双氯芬酸钠。抗凝血剂,如双甾烷醇,双吡啶醇。抗抑郁药,比如阿莫西平。抗糖尿病如格列吡嗪。抗菌药物如利奈唑胺,抗高血压药物如氨氯地平,米诺地尔,硝苯地平最好立即释放
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