Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Food Science and Human Wellness Pub Date : 2024-05-27 DOI:10.26599/FSHW.2022.9250156

Yuanyuan Wang , Lirong Dong , Meng Zhao , Shiyu Yin , Pan Da , Dengfeng Xu , Yifei Lu , Jiayue Xia , Niannian Wang , Shaokang Wang , Guiju Sun

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Abstract

Mental disorders seriously affect people's health and social stability. This Mendelian randomization (MR) study was designed to investigate the causal relationship between circulating vitamin C (VC) or 25-hydroxyvitamin D (25(OH)D) levels and mental disorders. The data used for the MR analysis were derived from the summary genome-wide association studies (GWAS) database for VC and 25(OH)D and from the FinnGen consortium for fourteen mental disorders. Based on the inverse variance weighted (IVW) method, we found a potential causal association between circulating VC and anxiety disorders (IVW: OR=1.139, 95 %CI: 1.0231.269, P = 0.018). However, no causal association was found between VC or 25(OH)D and other mental disorders (P > 0.05). In the reverse MR analysis, individuals with Alzheimer's disease was causally associated with higher concentrations of circulating VC(P = 0.012), while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D (P = 0.012). However, the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders. In addition, there was no causal association between circulating VC and 25(OH)D (P > 0.05). Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.

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循环维生素 C 和 25- 羟维生素 D 浓度与常见精神障碍之间的因果关系--孟德尔随机研究

精神障碍严重影响人们的健康和社会稳定。这项孟德尔随机化（MR）研究旨在调查循环维生素C（VC）或25-羟基维生素D（25(OH)D）水平与精神障碍之间的因果关系。用于MR分析的数据来自VC和25（OH）D的全基因组关联研究（GWAS）汇总数据库，以及14种精神障碍的FinnGen联盟。根据逆方差加权（IVW）方法，我们发现循环 VC 与焦虑症之间存在潜在的因果关系（IVW：OR=1.139，95 %CI：1.0231.269，P = 0.018）。然而，没有发现 VC 或 25(OH)D 与其他精神障碍之间存在因果关系（P > 0.05）。在反向 MR 分析中，阿尔茨海默氏症患者与较高的循环 VC 浓度之间存在因果关系（P = 0.012），而焦虑症患者与 25（OH）D 浓度之间存在负相关（P = 0.012）。然而，目前的证据并不支持 VC 或 25(OH)D 与其他精神障碍之间存在因果关系。此外，循环 VC 与 25（OH）D 之间也没有因果关系（P > 0.05）。未来的研究需要证实这些发现，并阐明潜在的因果关系机制。

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来源期刊

Food Science and Human Wellness Agricultural and Biological Sciences-Food Science

CiteScore

8.30

自引率

5.70%

发文量

审稿时长

28 days

期刊介绍： Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers.