Overcoming Complex Analytical Challenges Posed by Targeted Multispecific Antibody Cancer Therapeutics

IF 0.7 4区 化学 Q4 CHEMISTRY, ANALYTICAL Lc Gc North America Pub Date : 2023-10-01 DOI:10.56530/lcgc.na.fz8280l1
Mark Lies
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引用次数: 0

Abstract

Complex multispecific antibodies overcome the limitations of standard monoclonal antibodies (mAbs), and have complex three-dimensional structures, greater heterogeneity, and often novel disulfide linkages and unusual post-translational modifications. As a result, the comprehensive characterization essential to the development of cost-effective manufacturing processes and safe and efficacious cancer treatments is much more challenging using traditional analytical instruments and techniques. Fortunately, there are new solutions available that provide fast results, often with greater sensitivity and resolution, even for these novel, complex molecules. The application of various new methods and instruments for the analysis of multispecifics is discussed as a means of highlighting their ability to facilitate the development of these important new modalities.
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克服靶向多特异性抗体癌症治疗带来的复杂分析挑战
复杂的多特异性抗体克服了标准单克隆抗体(mab)的局限性,具有复杂的三维结构,更大的异质性,通常具有新颖的二硫键和不寻常的翻译后修饰。因此,综合表征对于开发具有成本效益的制造工艺和安全有效的癌症治疗至关重要,使用传统的分析仪器和技术更具挑战性。幸运的是,有新的解决方案可以提供快速的结果,通常具有更高的灵敏度和分辨率,甚至对于这些新的,复杂的分子也是如此。讨论了各种新方法和工具在分析多特性方面的应用,作为强调它们促进这些重要新模式发展的能力的手段。
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来源期刊
Lc Gc North America
Lc Gc North America 化学-分析化学
CiteScore
1.00
自引率
55.60%
发文量
0
审稿时长
2 months
期刊介绍: Founded in 1983, LCGC is the leading provider of digital and print content to the separation science market, enhancing the productivity, efficiency, and the overall value of separation techniques globally. Founded in 1983, LCGC is the leading provider of digital and print content to the separation science market, enhancing the productivity, efficiency, and the overall value of separation techniques globally. With our commitment to editorial excellence we have pioneered innovation across a broad portfolio of digital and print platforms.
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