Primary cilia in the development of the cerebral cortex: a literature review

Ting Peng, Yan Cheng, Man Xiong, Wen-Hao Zhou, Guo-Qiang Cheng
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Abstract

Background and Objective: Evolutionarily speaking, cilia are conserved organelles protruding from the surface of most cells, found in various cellular organisms. For a long period, primary cilia were considered as vestigial or useless organelles in the body. However, with the in-depth study of ultrastructure over recent years, researchers have discovered that abnormal primary cilia involved in corticogenesis could impose severe cilia-related cortical developmental defects or diseases. Till now, the specific mechanisms as well as pathogenesis remain unclear. Further studies are needed to explore the pathogenesis and treatment of ciliopathies associated with neurodevelopmental disorders.
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初级纤毛在大脑皮层发育中的作用:文献综述
背景与目的:从进化角度来看,纤毛是大多数细胞表面突出的保守细胞器,存在于各种细胞生物中。长期以来,初级纤毛被认为是机体中退化或无用的细胞器。然而,随着近年来对纤毛超微结构研究的深入,研究人员发现异常的纤毛参与皮质发生可导致严重的纤毛相关皮质发育缺陷或疾病。目前,其具体机制及发病机制尚不清楚。神经发育障碍相关纤毛病的发病机制和治疗方法有待进一步研究。
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