Current development status of accelerator-based neutron source for boron neutron capture therapy

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-10-05 DOI:10.1140/epjti/s40485-023-00105-5

Hiroaki Kumada, Takeji Sakae, Hideyuki Sakurai

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Abstract

Abstract Recently, progress in technology for accelerator-based neutron sources has increased attention regarding boron neutron capture therapy (BNCT). BNCT is a type of radiotherapy that combines neutrons and boron drugs and is expected to be used in the treatment of refractory and recurrent cancers. Owing to the need for high-intensity neutrons in treatment, compact accelerator-based neutron sources applicable to BNCT are being developed worldwide. These current projects utilize cyclotrons, linear accelerators, and electrostatic accelerators as accelerators for BNCT devices. Beryllium and lithium are the main target materials for neutron generation. The accelerators for BNCT device are required to accelerate charged particles with an average current ranging from a few milliamperes to a few tens of milliamperes in order to generate neutrons of sufficient intensity for the treatment. Moreover, the target systems require technologies and mechanisms that can withstand the large heat load produced by high-power beam irradiation and prevent blistering. This review outlines and explains the accelerator neutron sources for BNCT and the requirements for the components of each device, such as the accelerator, target material, and beam shaping assembly. In addition, various development projects for accelerator-based BNCT devices worldwide are introduced.

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硼中子俘获治疗用加速器中子源的发展现状

近年来，基于加速器的中子源技术的进步引起了人们对硼中子俘获治疗(BNCT)的关注。BNCT是一种结合中子和硼药物的放射疗法，有望用于治疗难治性和复发性癌症。由于在处理过程中需要高强度中子，世界各地正在开发适用于BNCT的紧凑型加速器中子源。这些目前的项目利用回旋加速器、线性加速器和静电加速器作为BNCT设备的加速器。铍和锂是中子生成的主要靶材料。BNCT装置的加速器需要以平均电流在几毫安到几十毫安之间的速度加速带电粒子，以产生足够强度的中子进行处理。此外，目标系统需要能够承受高功率光束照射产生的大热负荷并防止起泡的技术和机制。本文概述并解释了BNCT的加速器中子源以及每个设备组件的要求，例如加速器，目标材料和束整形组件。此外，还介绍了世界范围内基于加速器的BNCT器件的各种开发项目。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.