"The Effects of Growth Disorder-Related Mutations on The Conformational Structure of Insulin-like Growth Factor (IGF1): An In Silico Study"

Abstract

Insulin-like Growth Factor-1 (IGF1) is a hormone that plays a vital role in human growth and development. It regulates cell proliferation and tissue growth. Any alterations in the structure or function of IGF1 can have profound implications for various functions and diseases, including cancer and growth disorders. In this study, a comprehensive computational analysis was performed to examine the impact of single amino acid substitutions on IGF1 tertiary structure. The study involved using In Silico tools for comparing the amino acid sequences of wild-type and three variant IGF1 proteins, as well as assessing their physicochemical properties.