{"title":"Contributions of probiotic L. acidophilus 291 as biotechnological tool in therapeutic applications","authors":"Mukesh Verma, Baljeet Singh Saharan, Anil Kumar","doi":"10.25303/1809rjbt1470154","DOIUrl":null,"url":null,"abstract":"The present study was carried out to evaluate the hypoglycemic ability and antioxidant activities of lactic acid bacterial strain L. acidophilus NCDC 291 and to investigate the probiotic characteristics of the strain as well as its suitability as an alternative antimutagenic agent. The antidiabetic activity was examined by evaluating the α-glucosidase and α-amylase inhibitory activities. Strain L. acidophilus NCDC 291 exhibited hypoglycemic ability by α-glucosidase (41.67 %) and α-amylase (61.79 %). Strain L. acidophilus NCDC 291 showed antioxidant activities by DPPH (53.58 % and IC50 67.87 μL) and ABTS (50.61 % and IC50 45.17 μL). Further the bacterial strain was resistant to simulated gastrointestinal juice and showed potential for health promotion based on adhesion, antibiotic susceptibility and antimicrobial activities. L. acidophilus NCDC 291 appears as potential probiotic with beneficial health effects.","PeriodicalId":21091,"journal":{"name":"Research Journal of Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Journal of Biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25303/1809rjbt1470154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
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Abstract
The present study was carried out to evaluate the hypoglycemic ability and antioxidant activities of lactic acid bacterial strain L. acidophilus NCDC 291 and to investigate the probiotic characteristics of the strain as well as its suitability as an alternative antimutagenic agent. The antidiabetic activity was examined by evaluating the α-glucosidase and α-amylase inhibitory activities. Strain L. acidophilus NCDC 291 exhibited hypoglycemic ability by α-glucosidase (41.67 %) and α-amylase (61.79 %). Strain L. acidophilus NCDC 291 showed antioxidant activities by DPPH (53.58 % and IC50 67.87 μL) and ABTS (50.61 % and IC50 45.17 μL). Further the bacterial strain was resistant to simulated gastrointestinal juice and showed potential for health promotion based on adhesion, antibiotic susceptibility and antimicrobial activities. L. acidophilus NCDC 291 appears as potential probiotic with beneficial health effects.
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