Association of serum uric acid with metabolic syndrome components in Syrian population

Abstract

The current study aimed to investigate the correlation between serum uric acid levels and metabolic syndrome and its components in adult patients from Homs, Syria. This study included 86 subjects divided into two groups; 20 healthy controls and 66 patients with metabolic syndrome. Physical examination and blood pressure (BP) information were recorded. Serum uric acid (SUA), fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were tested. As a result, subjects with metabolic syndrome had significantly higher levels of SUA than controls (P < 0.001). Metabolic syndrome patients with hyperuricemia had higher BMI, WC, TC and LDL-C than those with normal uric acid levels (P < 0.05). Moreover, subjects with more metabolic syndrome components had higher SUA levels. On the other hand, SUA was positively correlated with WC, DBP, FBG, TG, TC and LDL-C and negatively with HDL-C (P < 0.05). Therefore, in general, elevated SUA levels appear to be positively associated with metabolic syndrome components in Syrian population and can be considered a therapeutic target in controlling metabolic syndrome disorders.