Pub Date : 2023-09-07DOI: 10.21608/bfsa.2023.226485.1850
Heba Yehia
Aromatherapy was practiced since prehistory for alleviating diseases and/or stress relief. Recently, it bloomed after complementary and alternative medicine became popular among individuals seeking homeopathic treatment to evade side effects. Studies revealed that aromatherapy owes its efficacy to complex essential oils that show qualitative and quantitative variabilities depending on plant-related factors. Aromatherapy is delivered through inhalation and dermal contact where volatile oils act locally or penetrate to the circulation to exert systemic effect. Many essential oils possess antibacterial, antifungal, antiviral and/or cytotoxic activities which raises concern against their random use and believing they are completely safe. Also, little evidence exists depicting the selectivity of essential oils towards pathogenic rather than endogenous microbiota. Relevantly, microflora dysbiosis can negatively impact the host’s health. Therefore, this article aims to emphasize that long-term studies are required to regulate aromatherapy practice without endangering the body’s homeostasis and refute the misleading assumption of its unquestionable safety.
{"title":"Aromatherapy apropos of normal flora: friend or foe?","authors":"Heba Yehia","doi":"10.21608/bfsa.2023.226485.1850","DOIUrl":"https://doi.org/10.21608/bfsa.2023.226485.1850","url":null,"abstract":"Aromatherapy was practiced since prehistory for alleviating diseases and/or stress relief. Recently, it bloomed after complementary and alternative medicine became popular among individuals seeking homeopathic treatment to evade side effects. Studies revealed that aromatherapy owes its efficacy to complex essential oils that show qualitative and quantitative variabilities depending on plant-related factors. Aromatherapy is delivered through inhalation and dermal contact where volatile oils act locally or penetrate to the circulation to exert systemic effect. Many essential oils possess antibacterial, antifungal, antiviral and/or cytotoxic activities which raises concern against their random use and believing they are completely safe. Also, little evidence exists depicting the selectivity of essential oils towards pathogenic rather than endogenous microbiota. Relevantly, microflora dysbiosis can negatively impact the host’s health. Therefore, this article aims to emphasize that long-term studies are required to regulate aromatherapy practice without endangering the body’s homeostasis and refute the misleading assumption of its unquestionable safety.","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135049070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-06DOI: 10.21608/bfsa.2023.217447.1779
Ghufran Hamid, Iead Othman, Sulaf Alwassouf
The current study aimed to investigate the correlation between serum uric acid levels and metabolic syndrome and its components in adult patients from Homs, Syria. This study included 86 subjects divided into two groups; 20 healthy controls and 66 patients with metabolic syndrome. Physical examination and blood pressure (BP) information were recorded. Serum uric acid (SUA), fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were tested. As a result, subjects with metabolic syndrome had significantly higher levels of SUA than controls (P < 0.001). Metabolic syndrome patients with hyperuricemia had higher BMI, WC, TC and LDL-C than those with normal uric acid levels (P < 0.05). Moreover, subjects with more metabolic syndrome components had higher SUA levels. On the other hand, SUA was positively correlated with WC, DBP, FBG, TG, TC and LDL-C and negatively with HDL-C (P < 0.05). Therefore, in general, elevated SUA levels appear to be positively associated with metabolic syndrome components in Syrian population and can be considered a therapeutic target in controlling metabolic syndrome disorders.
{"title":"Association of serum uric acid with metabolic syndrome components in Syrian population","authors":"Ghufran Hamid, Iead Othman, Sulaf Alwassouf","doi":"10.21608/bfsa.2023.217447.1779","DOIUrl":"https://doi.org/10.21608/bfsa.2023.217447.1779","url":null,"abstract":"The current study aimed to investigate the correlation between serum uric acid levels and metabolic syndrome and its components in adult patients from Homs, Syria. This study included 86 subjects divided into two groups; 20 healthy controls and 66 patients with metabolic syndrome. Physical examination and blood pressure (BP) information were recorded. Serum uric acid (SUA), fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were tested. As a result, subjects with metabolic syndrome had significantly higher levels of SUA than controls (P < 0.001). Metabolic syndrome patients with hyperuricemia had higher BMI, WC, TC and LDL-C than those with normal uric acid levels (P < 0.05). Moreover, subjects with more metabolic syndrome components had higher SUA levels. On the other hand, SUA was positively correlated with WC, DBP, FBG, TG, TC and LDL-C and negatively with HDL-C (P < 0.05). Therefore, in general, elevated SUA levels appear to be positively associated with metabolic syndrome components in Syrian population and can be considered a therapeutic target in controlling metabolic syndrome disorders.","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135204628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-02DOI: 10.21608/bfsa.2023.219620.1790
Mais Al-Hamdani, Sarmed Noori, Amira Kassem
Indeed, because of their potential to overcome some of the limitations of synthetic polymer-based nanoparticles
{"title":"Advancements in Nanoparticle-Based RNA Therapeutics and RNA Delivery Systems","authors":"Mais Al-Hamdani, Sarmed Noori, Amira Kassem","doi":"10.21608/bfsa.2023.219620.1790","DOIUrl":"https://doi.org/10.21608/bfsa.2023.219620.1790","url":null,"abstract":"Indeed, because of their potential to overcome some of the limitations of synthetic polymer-based nanoparticles","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134968820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential Protective Effects of Mesna and Vitamin D Separately or Concomitantly on Cyclophosphamide Induced Hemorrhagic Cystitis in Rats","authors":"Mennatallah Elkady, Heba Mahmoud, Samia Abo Elsood, Mahmoud Abdel halim","doi":"10.21608/bfsa.2023.223474.1824","DOIUrl":"https://doi.org/10.21608/bfsa.2023.223474.1824","url":null,"abstract":"","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135248351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.21608/bfsa.2023.223343.1823
Mona Mohamed, Gamal Gouda, Adham Nagiub
The aim of this research is to use red onion extract (Allium cepa) in the green synthesis of zinc oxide nanoparticles (ZnO NPs). With an average crystal size of 8.13 nm, X-ray diffraction (XRD) scanning was used to determine the hexagonal wurtzite structure of the ZnO NPs. Infrared spectra (FT-IR) provided evidence of capping and biogenesis stability of ZnO NPs. The absorption peak at 374 nm with an energy gap of 3.32 eV was determined by surface plasmon resonance via UV-visible analysis. Morphological analysis was performed
{"title":"Biosynthesis and antibacterial evaluation of zinc oxide nanoparticles from Onion extract (Allium cepa)","authors":"Mona Mohamed, Gamal Gouda, Adham Nagiub","doi":"10.21608/bfsa.2023.223343.1823","DOIUrl":"https://doi.org/10.21608/bfsa.2023.223343.1823","url":null,"abstract":"The aim of this research is to use red onion extract (Allium cepa) in the green synthesis of zinc oxide nanoparticles (ZnO NPs). With an average crystal size of 8.13 nm, X-ray diffraction (XRD) scanning was used to determine the hexagonal wurtzite structure of the ZnO NPs. Infrared spectra (FT-IR) provided evidence of capping and biogenesis stability of ZnO NPs. The absorption peak at 374 nm with an energy gap of 3.32 eV was determined by surface plasmon resonance via UV-visible analysis. Morphological analysis was performed","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.21608/bfsa.2023.210650.1746
Israa Jalal, Shimaa Mohamed, Abeer Elkhoely, Amany Ahmed
Hyperhomocysteinemia (HHcy) was found to be a risk factor for cardiovascular disorders and many other diseases. HHcy occurs when homocysteine (Hcy) exceeds 15 μmol/L. The prevalence of HHcy ranges from 5 – 10% in the general adult population. HHcy can cause atherosclerosis and heart dysfunction through oxidative stress, inflammation, endothelial interaction with leukocytes, coagulation, endothelial fibrosis, SMCs proliferation, apoptosis, lipids dysregulation, epigenetic modifications and modifications of electrical conduction in the heart. Some of the drugs that have been studied have been shown to be effective in reducing the level of HHcy. Conclusion: High Hcy level can be a strong cause in several disorders including cardiovascular diseases. So, serious effort should be made to avoid and treat HHcy. All evidence suggests that Hcy is causally connected to atherosclerosis by many mechanisms. But future studies should concentrate on the molecular pathways of HHcy in cardiac dysfunction, and the effects of Hcy-lowering medications on cardiac dysfunction.
{"title":"Hyperhomocysteinemia: its impact on cardiovascular disease and atherosclerosis","authors":"Israa Jalal, Shimaa Mohamed, Abeer Elkhoely, Amany Ahmed","doi":"10.21608/bfsa.2023.210650.1746","DOIUrl":"https://doi.org/10.21608/bfsa.2023.210650.1746","url":null,"abstract":"Hyperhomocysteinemia (HHcy) was found to be a risk factor for cardiovascular disorders and many other diseases. HHcy occurs when homocysteine (Hcy) exceeds 15 μmol/L. The prevalence of HHcy ranges from 5 – 10% in the general adult population. HHcy can cause atherosclerosis and heart dysfunction through oxidative stress, inflammation, endothelial interaction with leukocytes, coagulation, endothelial fibrosis, SMCs proliferation, apoptosis, lipids dysregulation, epigenetic modifications and modifications of electrical conduction in the heart. Some of the drugs that have been studied have been shown to be effective in reducing the level of HHcy. Conclusion: High Hcy level can be a strong cause in several disorders including cardiovascular diseases. So, serious effort should be made to avoid and treat HHcy. All evidence suggests that Hcy is causally connected to atherosclerosis by many mechanisms. But future studies should concentrate on the molecular pathways of HHcy in cardiac dysfunction, and the effects of Hcy-lowering medications on cardiac dysfunction.","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135162844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/bfsa.2023.301162
Heba El-Kady, Hosny Hassan, Amal Mohamed, Lourin Malak, Sary El-Ghaffar
{"title":"THERAPEUTIC PHARMACOLOGICAL PROPERTIES OF CITRULLUS COLOCYNTHIS FRUIT PULPS METHANOLIC CRUDE EXTRACT AGAINST POTASSIUM OXONATE-INDUCED HYPERURICEMIC GOUT RAT MODEL","authors":"Heba El-Kady, Hosny Hassan, Amal Mohamed, Lourin Malak, Sary El-Ghaffar","doi":"10.21608/bfsa.2023.301162","DOIUrl":"https://doi.org/10.21608/bfsa.2023.301162","url":null,"abstract":"","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134903769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/bfsa.2023.300941
Amany Ghanim, Hend Abd El-wahab
{"title":"SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF DIARYLIMIDAZOLE DERIVATIVES AS NEW POTENTIAL ANTI-INFLAMMATORY AGENTS TARGETING COX-2 ENZYME","authors":"Amany Ghanim, Hend Abd El-wahab","doi":"10.21608/bfsa.2023.300941","DOIUrl":"https://doi.org/10.21608/bfsa.2023.300941","url":null,"abstract":"","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134903774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/bfsa.2023.301132
Shimaa Ghanem, Gamal Gad, Rehab Abd El-Baky, Nancy F. M. Waly
{"title":"ASSOCIATION BETWEEN ANTIBIOTIC RESISTANCE, BIOFILM FORMATION AND LASB GENE IN PSEUDOMONAS AERUGINOSA ISOLATED FROM DIFFERENT CLINICAL SPECIMENS","authors":"Shimaa Ghanem, Gamal Gad, Rehab Abd El-Baky, Nancy F. M. Waly","doi":"10.21608/bfsa.2023.301132","DOIUrl":"https://doi.org/10.21608/bfsa.2023.301132","url":null,"abstract":"","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134903782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"APPLICATION OF ASPERGILLUS ORYZAE ASU44 (OL314732) AND THEIR KOJIC ACID AS PESTICIDES AGAINST COTTON APHID, APHIS GOSSYPII","authors":"Ghada Mahmoud, Abdel- Naser Zohri, Nahla Kamal-Eldin, Nourelhoda Abdelhamid","doi":"10.21608/bfsa.2023.300763","DOIUrl":"https://doi.org/10.21608/bfsa.2023.300763","url":null,"abstract":"","PeriodicalId":55311,"journal":{"name":"Bulletin of Pharmaceutical Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134903784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：