Identification of two phthalide derivatives and an oxindole compound isolated from the edible mushroom <i>Pleurotus ostreatus</i> and their inhibitory activities against plant pathogenic microorganisms

IF 1.5 4区 农林科学 Q2 ENTOMOLOGY Journal of Pesticide Science Pub Date : 2023-01-01 DOI:10.1584/jpestics.d23-039
Enrico M. Cabutaje, Kotomi Ueno, Kumiko Osaki-Oka, Kazutaka Kido, Thomas Edison E. dela Cruz, Atsushi Ishihara
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Abstract

The excessive use of chemical pesticides in agricultural fields for controlling plant pathogenic microorganisms harms human health, the environment, and other beneficial microorganisms in the soil and plants. To address this challenge, it is essential to isolate and discover bioactive compounds from biological resources that could inhibit plant pathogenic microorganisms. In this study, the culture filtrate of the edible mushroom Pleurotus ostreatus was subjected to bioassay-guided isolation, and two phthalide derivatives—4,6-dimethoxyphthalide (1) and 5,7-dimethoxyphthalide (2)—were identified, along with an oxindole compound—3-hydroxy-3-methyloxindole (3). The inhibitory activities of the three compounds were evaluated against four fungal and five bacterial pathogens. Remarkably, 1 and 2 exhibited the lowest IC50 values against the conidial germination and germ tube elongation of the rice blast fungus Pyricularia oryzae. However, their effectiveness against bacterial pathogens was relatively low. The (S) and (R)-enantiomers of 3-hydroxy-3-methyloxindole showed different activities against plant fungal pathogens and bacterial plant pathogens.
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食用菌平菇(Pleurotus ostreatus</i>)中两个邻苯酞衍生物和一个氧化吲哚化合物的鉴定及其对植物病原微生物的抑制作用
为了控制植物病原微生物,在农业领域过量使用化学农药危害人类健康、环境以及土壤和植物中的其他有益微生物。为了应对这一挑战,必须从生物资源中分离和发现能够抑制植物病原微生物的生物活性化合物。本研究对食用菌平菇(Pleurotus ostreatus)的培养滤液进行了生物测定指导分离,鉴定出两种邻苯酞衍生物4,6-二甲氧基酞(1)和5,7-二甲氧基酞(2),以及一种氧吲哚化合物-3-羟基-3-甲基氧吲哚(3),并对这三种化合物对四种真菌和五种细菌病原体的抑制活性进行了评价。值得注意的是,1号和2号对稻瘟病菌孢子萌发和胚管伸长的IC50值最低。然而,它们对细菌病原体的有效性相对较低。3-羟基-3-甲基氧吲哚的(S)和(R)-对映体对植物真菌病原菌和细菌病原菌表现出不同的活性。
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来源期刊
Journal of Pesticide Science
Journal of Pesticide Science 农林科学-昆虫学
CiteScore
4.30
自引率
4.20%
发文量
28
审稿时长
18-36 weeks
期刊介绍: The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.
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