Viability Base Gel as Potential for Fabricating Crassostrea gigas hydroxyapatite (HA-Crassostrea gigas shell) Gel for Dental Caries Repair

IF 0.5 Q4 ENGINEERING, BIOMEDICAL Journal of Biomimetics, Biomaterials and Biomedical Engineering Pub Date : 2023-10-24 DOI:10.4028/p-ly1ksh

Aminatun Nisa, Mona Sari, Yusril Yusuf

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Abstract

This study aims to create a gel base composition that has the potential to be combined with hydroxyapatite from the biogenic material Crassostrea gigas as a gel that can repair dental caries. The base gel composition consists of Na-CMC, guar gum, and glycerin which can dissolve the HA element without settling so that it can be applied well to the teeth. nano HA contained in Crassostrea gigas can potentially remineralize and improve caries in teeth. Therefore, it is inevitable that the base gel is safe to make composites with nano HA as a function of repairing dental caries. The potential of HA as a tooth remineralization material was proven by the SEM, FTIR, and XRD characterization of CaCO 3 and CaO, which have sharp crystallinity. The base gel is safe to be applied to the bones of the teeth by the MTT test treatment. This proves that the base gel is not toxic and has high viability of 92.66% at a dose of 31.25 μg/mL. The IC50 value was 688.6 μg/ml. These results are safe to be applied with nano HA material and are safe to be applied to the bones of the teeth.

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活力基凝胶制备长牡蛎羟基磷灰石(HA-长牡蛎壳)龋齿修复凝胶

本研究旨在创造一种凝胶基组合物，该组合物具有与生物材料长牡蛎中的羟基磷灰石结合的潜力，作为一种可以修复龋齿的凝胶。基础凝胶成分由Na-CMC，瓜尔胶和甘油组成，可以溶解HA元素而不沉淀，因此可以很好地涂抹在牙齿上。长牡蛎中含有的纳米透明质酸具有潜在的再矿化和改善牙齿龋齿的作用。因此，将纳米透明质酸作为修复龋的复合材料，其基础凝胶的安全性是必然的。通过对结晶度较高的caco3和CaO的SEM、FTIR和XRD表征，证实了透明质酸作为牙齿再矿化材料的潜力。通过MTT测试处理，基凝胶可以安全地应用于牙齿骨骼。结果表明，在31.25 μg/mL的剂量下，该基础凝胶无毒，活性高达92.66%。IC50值为688.6 μg/ml。这些结果可以安全地应用于纳米透明质酸材料，并且可以安全地应用于牙齿骨骼。

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