Zhi Feng Zhou, Da Tao Xu, Hui Yu Zhou, T. Chon, Julien S. Baker, Yaodong Gu
Background: Patients with chronic ankle instability (CAI) demonstrated altered movement patterns during unanticipated landing compared to coper patients. Understanding the effects of kinematics, dynamics and energetics on individual movement patterns during landing could enhance motor control strategies for patients with ankle sprains while avoiding the transition of coper patients to CAI patients. Therefore, the purpose of this study was to investigate the differences in movement patterns of coper patients compared to CAI patients during the unanticipated landings; Methods: Fifteen individuals with CAI (age: 22.8±1.4 years; height: 180.1±4.2 cm; weight: 81.5±5.8 kg) and fifteen copers (age: 23.1±1.2 years; height: 179.8±4.4 cm, weight: 80.4±6.2 kg) participated in an unanticipated landing task, during which three-dimensional motion capture, ground reaction force (GRF), and muscle activation data were collected. A musculoskeletal model was used to estimate muscle force and joint power among these two groups. Joint power was calculated as the product of angular velocity in the sagittal plane and joint moment data, reflecting the energy transfer at the ankle, knee, and hip joints. Furthermore, energy dissipation and generation within these joints were determined by integrating specific regions of the joint power curve; Results: Individuals with CAI demonstrated a greater muscle force in the vastus lateralis compared copers during the unanticipated landing task, while copers exhibited higher peak muscle forces in the medial gastrocnemius (p=0.007), lateral gastrocnemius (p=0.002), soleus (p=0.004). The muscle activation patterns of CAI patients also differ from those of coper patients. Compared to copers, CAI patients exhibit earlier activation of the rectus femoris (p<0.001) and lateral gastrocnemius muscles (p=0.042). Conversely, copers demonstrate earlier activation of the soleus (p=0.004) and medial gastrocnemius (p=0.003) muscles. In addition, joint power in CAI individuals during unanticipated landing shifted from the ankle to the knee and hip (p<0.001); Conclusions: These findings suggest that individuals with CAI exhibit a change in motion control strategy during unanticipated landing tasks. The variations in peak forces and the ability of proximal muscles to generate force might enable them to offset the deficits noted in distal muscles. Energy redistribution issues observed in CAI patients may help to prevent the transition of coper patients towards developing CAI patients.
背景：慢性踝关节不稳定（CAI）患者在意外着地时的运动模式与踝关节扭伤患者相比有所改变。了解运动学、动力学和能量学对着地时个人运动模式的影响，可以加强踝关节扭伤患者的运动控制策略，同时避免踝关节扭伤患者转变为 CAI 患者。因此，本研究的目的是调查踝关节扭伤患者与 CAI 患者在意外着地时运动模式的差异：15 名 CAI 患者（年龄：22.8±1.4 岁；身高：180.1±4.2 厘米；体重：81.5±5.8 千克）和 15 名匍匐前进者（年龄：23.1±1.2 岁；身高：179.8±4.4 厘米；体重：80.4±6.2 千克）参加了非预期着陆任务，在此期间收集了三维运动捕捉、地面反作用力（GRF）和肌肉激活数据。我们使用肌肉骨骼模型来估算这两组人的肌肉力量和关节力量。关节力量是根据矢状面角速度与关节力矩数据的乘积计算得出的，反映了踝关节、膝关节和髋关节的能量传递情况。此外，通过整合关节力量曲线的特定区域，确定了这些关节内的能量耗散和产生情况；结果显示：CAI 患者的肌肉力量和关节力量均高于其他患者：在非预期着地任务中，CAI 患者的外侧阔肌的肌力大于应付者，而应付者的内侧腓肠肌（p=0.007）、外侧腓肠肌（p=0.002）和比目鱼肌（p=0.004）的峰值肌力更高。CAI 患者的肌肉激活模式也与共济失调患者不同。与共济失调患者相比，CAI 患者更早激活股直肌（p<0.001）和腓肠肌外侧（p=0.042）。相反，CAI 患者比目鱼肌（p=0.004）和腓肠肌内侧（p=0.003）的激活较早。此外，在意外着地时，CAI 患者的关节力量从踝关节转移到了膝关节和髋关节（p<0.001）；结论：这些研究结果表明，CAI 患者在意外着陆任务中的运动控制策略发生了变化。峰值力的变化和近端肌肉产生力的能力可能使它们能够抵消远端肌肉的缺陷。在 CAI 患者身上观察到的能量再分配问题可能有助于防止共济失调患者向发展型 CAI 患者过渡。
{"title":"Distinct Motion Control Strategy during Unanticipated Landing: Transitioning from Copers to Chronic Ankle Instability","authors":"Zhi Feng Zhou, Da Tao Xu, Hui Yu Zhou, T. Chon, Julien S. Baker, Yaodong Gu","doi":"10.4028/p-s3ka1k","DOIUrl":"https://doi.org/10.4028/p-s3ka1k","url":null,"abstract":"Background: Patients with chronic ankle instability (CAI) demonstrated altered movement patterns during unanticipated landing compared to coper patients. Understanding the effects of kinematics, dynamics and energetics on individual movement patterns during landing could enhance motor control strategies for patients with ankle sprains while avoiding the transition of coper patients to CAI patients. Therefore, the purpose of this study was to investigate the differences in movement patterns of coper patients compared to CAI patients during the unanticipated landings; Methods: Fifteen individuals with CAI (age: 22.8±1.4 years; height: 180.1±4.2 cm; weight: 81.5±5.8 kg) and fifteen copers (age: 23.1±1.2 years; height: 179.8±4.4 cm, weight: 80.4±6.2 kg) participated in an unanticipated landing task, during which three-dimensional motion capture, ground reaction force (GRF), and muscle activation data were collected. A musculoskeletal model was used to estimate muscle force and joint power among these two groups. Joint power was calculated as the product of angular velocity in the sagittal plane and joint moment data, reflecting the energy transfer at the ankle, knee, and hip joints. Furthermore, energy dissipation and generation within these joints were determined by integrating specific regions of the joint power curve; Results: Individuals with CAI demonstrated a greater muscle force in the vastus lateralis compared copers during the unanticipated landing task, while copers exhibited higher peak muscle forces in the medial gastrocnemius (p=0.007), lateral gastrocnemius (p=0.002), soleus (p=0.004). The muscle activation patterns of CAI patients also differ from those of coper patients. Compared to copers, CAI patients exhibit earlier activation of the rectus femoris (p<0.001) and lateral gastrocnemius muscles (p=0.042). Conversely, copers demonstrate earlier activation of the soleus (p=0.004) and medial gastrocnemius (p=0.003) muscles. In addition, joint power in CAI individuals during unanticipated landing shifted from the ankle to the knee and hip (p<0.001); Conclusions: These findings suggest that individuals with CAI exhibit a change in motion control strategy during unanticipated landing tasks. The variations in peak forces and the ability of proximal muscles to generate force might enable them to offset the deficits noted in distal muscles. Energy redistribution issues observed in CAI patients may help to prevent the transition of coper patients towards developing CAI patients.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141813533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Ajala, P. Adegbite, A. Obalalu, Amir Abbas, Abel O Owolabi, O. B. Ojewola
The focal concern of this study is to examine the behaviour of bio-convective flow featuring micropolar nanofluids over an inclined permeable stretching surface while considering the influence of radiative activation energy. This investigation addresses the complex interplay of factors such as biological activity, convective heat and mass transfer, unique attributes of micropolar fluids, the dynamics of nanofluids, and radiative effects. This analysis employed Buongiorno’s model, considering thermal radiation and activation energy on the bioconvective flow of micropolar nanofluids over an inclined stretching surface. Some suitable similarity variables were used to obtain a set of non-linear differential equations from the initial partial differential equations which were then solved numerically using the Runge-Kutta Fehberg method along with shooting technique. The effects of some physical parameters were examined on the velocity, temperature, concentration, and microorganism density profiles of the flow. The result revealed that each increase in the heat source/sink, thermal radiation, thermophoresis, and Brownian motion lead to a corresponding increase in the thermal boundary layer; activation energy increased the concentration while Peclet number and bioconvective Lewis number declined the microorganism density profile. Insights gleaned from this study can find applications in biomedical fields. Understanding the behavior of bio-convective nanofluids has implications for controlled heat transfer in medical applications like hyperthermia treatments or targeted drug delivery, thereby impacting patient care.
{"title":"Bio-Convective Flow of Micropolar Nanofluids over an Inclined Permeable Stretching Surface with Radiative Activation Energy","authors":"O. Ajala, P. Adegbite, A. Obalalu, Amir Abbas, Abel O Owolabi, O. B. Ojewola","doi":"10.4028/p-c79r3y","DOIUrl":"https://doi.org/10.4028/p-c79r3y","url":null,"abstract":"The focal concern of this study is to examine the behaviour of bio-convective flow featuring micropolar nanofluids over an inclined permeable stretching surface while considering the influence of radiative activation energy. This investigation addresses the complex interplay of factors such as biological activity, convective heat and mass transfer, unique attributes of micropolar fluids, the dynamics of nanofluids, and radiative effects. This analysis employed Buongiorno’s model, considering thermal radiation and activation energy on the bioconvective flow of micropolar nanofluids over an inclined stretching surface. Some suitable similarity variables were used to obtain a set of non-linear differential equations from the initial partial differential equations which were then solved numerically using the Runge-Kutta Fehberg method along with shooting technique. The effects of some physical parameters were examined on the velocity, temperature, concentration, and microorganism density profiles of the flow. The result revealed that each increase in the heat source/sink, thermal radiation, thermophoresis, and Brownian motion lead to a corresponding increase in the thermal boundary layer; activation energy increased the concentration while Peclet number and bioconvective Lewis number declined the microorganism density profile. Insights gleaned from this study can find applications in biomedical fields. Understanding the behavior of bio-convective nanofluids has implications for controlled heat transfer in medical applications like hyperthermia treatments or targeted drug delivery, thereby impacting patient care.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Areisman Salleh, A. Afifi, F. M. Zuki, Mastura Mohtar, R.A. Ilyas
In view of the growing concern over the threat of antibiotic resistance and bacterial infections, this study evaluated the antimicrobial performance and characteristics of chitosan/polyvinyl alcohol (PVA) nanofibers incorporated with Methylene Blue (MB). Following the fabrication of chitosan/PVA nanofibers loaded with different MB concentrations via electrospinning, the samples were characterised through Field-emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared (FTIR) spectroscopy, and leaching tests. Finally, the antimicrobial inhibition level of the samples was assessed via the disc diffusion method. Based on the results, the MB-integrated chitosan/PVA nanofibers exhibited a nanoscale morphology, and the FTIR confirmed the presence of MB. The findings also established a positive correlation between the MB concentration and leaching intensity. Furthermore, the optimal antimicrobial efficacy against Escherichia coli was achieved by the chitosan/PVA/MB (5 wt.%) sample with a 2-min laser exposure, which recorded a significant inhibition zone of 8.65 mm. In conclusion, MB demonstrated potent antimicrobial properties against E. coli, suggesting its potential integration in electrospun nanofibers for combating bacterial infections via photodynamic therapy.
{"title":"Improving Chitosan/PVA Electrospun Nanofibers Antimicrobial Efficacy with Methylene Blue for Effective E. Coli Inhibition Using Photodynamic Therapy","authors":"Areisman Salleh, A. Afifi, F. M. Zuki, Mastura Mohtar, R.A. Ilyas","doi":"10.4028/p-zs1pwj","DOIUrl":"https://doi.org/10.4028/p-zs1pwj","url":null,"abstract":"In view of the growing concern over the threat of antibiotic resistance and bacterial infections, this study evaluated the antimicrobial performance and characteristics of chitosan/polyvinyl alcohol (PVA) nanofibers incorporated with Methylene Blue (MB). Following the fabrication of chitosan/PVA nanofibers loaded with different MB concentrations via electrospinning, the samples were characterised through Field-emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared (FTIR) spectroscopy, and leaching tests. Finally, the antimicrobial inhibition level of the samples was assessed via the disc diffusion method. Based on the results, the MB-integrated chitosan/PVA nanofibers exhibited a nanoscale morphology, and the FTIR confirmed the presence of MB. The findings also established a positive correlation between the MB concentration and leaching intensity. Furthermore, the optimal antimicrobial efficacy against Escherichia coli was achieved by the chitosan/PVA/MB (5 wt.%) sample with a 2-min laser exposure, which recorded a significant inhibition zone of 8.65 mm. In conclusion, MB demonstrated potent antimicrobial properties against E. coli, suggesting its potential integration in electrospun nanofibers for combating bacterial infections via photodynamic therapy.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141813451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Journal of Biomimetics, Biomaterials and Biomedical Engineering Vol. 65","authors":"","doi":"10.4028/b-vpyea8","DOIUrl":"https://doi.org/10.4028/b-vpyea8","url":null,"abstract":"","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Selikane, T. Gumede, Katekani Shingange, T. Malevu, Mbongeni Ngwenya, Fisokuhle Kumalo
This study presents a comprehensive investigation into the preparation and characterization of PCL/EA cellulose composites. The Fourier-transform infrared (FTIR) spectroscopy results confirm the successful composite fabrication, indicating the absence of chemical reactions during melt-compounding. Scanning electron microscopy (SEM) revealed distinct morphologies, with PCL forming a continuous phase and EA cellulose exhibiting a fibrous network. Despite successful embedding of EA cellulose fibers in the composite, fractured surfaces indicated poor interfacial interaction, potentially leading to fiber pull out. Thermogravimetric analysis (TGA) revealed enhanced thermal stability in the composites, while differential scanning calorimetry (DSC) indicated minimal impact on PCL melting behavior. X-ray diffraction analysis (XRD) further demonstrated enhanced crystallinity in the composites, highlighting increased order in PCL crystals. Mechanical testing revealed a modest increase in stiffness attributed to the rigid cellulose fibers. However, a decrease in yield strength, tensile strength, and elongation at break suggested reduced ductility and inferior mechanical properties, consistent with poor interfacial adhesion observed in SEM. Overall, this study contributes valuable insights into the structural, thermal, and mechanical characteristics of PCL/EA cellulose composites, offering a foundation for potential applications in various fields.
本研究全面考察了 PCL/EA 纤维素复合材料的制备和表征。傅立叶变换红外光谱（FTIR）结果证实了复合材料的成功制备，表明在熔融共混过程中没有发生化学反应。扫描电子显微镜（SEM）显示了不同的形态，PCL 形成连续相，而 EA 纤维素则呈现纤维状网络。尽管 EA 纤维素纤维成功地嵌入了复合材料中，但断裂的表面表明界面相互作用不良，可能导致纤维脱落。热重分析（TGA）表明复合材料的热稳定性增强，而差示扫描量热法（DSC）表明对 PCL 熔化行为的影响极小。X 射线衍射分析（XRD）进一步表明，复合材料的结晶度提高，PCL 晶体的有序性增强。机械测试表明，刚性纤维素纤维适度提高了刚度。然而，屈服强度、拉伸强度和断裂伸长率的降低表明延展性降低，机械性能变差，这与扫描电镜观察到的界面粘附性差是一致的。总之，这项研究对 PCL/EA 纤维素复合材料的结构、热和机械特性提出了宝贵的见解，为其在各个领域的潜在应用奠定了基础。
{"title":"Characterization of Polycaprolactone/Eucomis autumnalis Cellulose Composite: Structural, Thermal, and Mechanical Analysis","authors":"D. Selikane, T. Gumede, Katekani Shingange, T. Malevu, Mbongeni Ngwenya, Fisokuhle Kumalo","doi":"10.4028/p-pt5csd","DOIUrl":"https://doi.org/10.4028/p-pt5csd","url":null,"abstract":"This study presents a comprehensive investigation into the preparation and characterization of PCL/EA cellulose composites. The Fourier-transform infrared (FTIR) spectroscopy results confirm the successful composite fabrication, indicating the absence of chemical reactions during melt-compounding. Scanning electron microscopy (SEM) revealed distinct morphologies, with PCL forming a continuous phase and EA cellulose exhibiting a fibrous network. Despite successful embedding of EA cellulose fibers in the composite, fractured surfaces indicated poor interfacial interaction, potentially leading to fiber pull out. Thermogravimetric analysis (TGA) revealed enhanced thermal stability in the composites, while differential scanning calorimetry (DSC) indicated minimal impact on PCL melting behavior. X-ray diffraction analysis (XRD) further demonstrated enhanced crystallinity in the composites, highlighting increased order in PCL crystals. Mechanical testing revealed a modest increase in stiffness attributed to the rigid cellulose fibers. However, a decrease in yield strength, tensile strength, and elongation at break suggested reduced ductility and inferior mechanical properties, consistent with poor interfacial adhesion observed in SEM. Overall, this study contributes valuable insights into the structural, thermal, and mechanical characteristics of PCL/EA cellulose composites, offering a foundation for potential applications in various fields.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polymethyl methacrylate (PMMA) is a polymer that is a suitable biomaterial for applications such as bone cement and replacement hip joints because it is inert, non-toxic, and has good mechanical properties. Hydroxyapatite (HA) is among the most thoroughly investigated bioceramics because its composition is similar to that of human bone and it has excellent biocompatibility and osteoconductive properties. Moreover, HA can be modified to regulate its physiochemical properties. In this study, boron and strontium were co-substituted into HA (SrBHA) to improve its biological characteristics. Previous studies have shown that strontium can increase bone density, although it negatively affects bone production. Moreover, boron helps to regulate the calcium balance to prevent bone loss. PMMA/SrBHA composites were prepared with different concentrations of SrBHA powder and the effects on the mechanical properties of the composites were investigated. The composites were fabricated using twin-screw extruders and compressed into test specimens using compression molding machinery. When the SrBHA powder concentration was <10 phr, the SrBHA particles were uniformly dispersed throughout the composite via a continuous polymer matrix reaction. Moreover, this concentration produced the greatest increase in compressive strength compared to the sample with no SrBHA (127.4 MPa). The composites were analyzed using energy-dispersive X-ray analysis, Fourier-transform infrared spectroscopy, and X-ray diffraction to determine the dispersion of the reinforced nanoparticles. Scanning electron microscopy (SEM) was used to analyze the dispersion of the SrBHA powder inside the matrix and to determine the causes of the fractures. The SrBHA powder improved the mechanical properties of PMMA, which is critical for applications in biomedical components. The mechanical tests and SEM analysis indicated that PMMA/SrBHA composites could be used for replacement joints and orthopedic implants.
聚甲基丙烯酸甲酯（PMMA）是一种聚合物，它具有惰性、无毒和良好的机械性能，是骨水泥和置换髋关节等应用的理想生物材料。羟基磷灰石（HA）是研究最深入的生物陶瓷之一，因为它的成分与人体骨骼相似，具有良好的生物相容性和骨传导性。此外，HA 还可以通过改性来调节其理化性质。本研究在 HA（SrBHA）中共同取代了硼和锶，以改善其生物特性。以往的研究表明，锶虽然对骨生成有负面影响，但可以增加骨密度。此外，硼有助于调节钙平衡，防止骨质流失。我们用不同浓度的 SrBHA 粉末制备了 PMMA/SrBHA 复合材料，并研究了其对复合材料机械性能的影响。复合材料使用双螺杆挤出机制造，并使用压缩成型机压缩成试样。当 SrBHA 粉末浓度小于 10 phr 时，SrBHA 颗粒通过连续的聚合物基质反应均匀地分散在整个复合材料中。此外，与不含 SrBHA 的样品（127.4 兆帕）相比，该浓度产生的抗压强度增幅最大。使用能量色散 X 射线分析法、傅立叶变换红外光谱法和 X 射线衍射法对复合材料进行了分析，以确定增强纳米粒子的分散情况。扫描电子显微镜（SEM）用于分析 SrBHA 粉末在基体内部的分散情况，并确定断裂的原因。SrBHA 粉末改善了 PMMA 的机械性能，这对生物医学部件的应用至关重要。机械测试和 SEM 分析表明，PMMA/SrBHA 复合材料可用于替换关节和骨科植入物。
{"title":"Preparation and Characterization of PMMA/SrBHA Composites for Bone Replacement Applications","authors":"Sirikarn Khansumled, Piyanan Boonphayak","doi":"10.4028/p-z8tko9","DOIUrl":"https://doi.org/10.4028/p-z8tko9","url":null,"abstract":"Polymethyl methacrylate (PMMA) is a polymer that is a suitable biomaterial for applications such as bone cement and replacement hip joints because it is inert, non-toxic, and has good mechanical properties. Hydroxyapatite (HA) is among the most thoroughly investigated bioceramics because its composition is similar to that of human bone and it has excellent biocompatibility and osteoconductive properties. Moreover, HA can be modified to regulate its physiochemical properties. In this study, boron and strontium were co-substituted into HA (SrBHA) to improve its biological characteristics. Previous studies have shown that strontium can increase bone density, although it negatively affects bone production. Moreover, boron helps to regulate the calcium balance to prevent bone loss. PMMA/SrBHA composites were prepared with different concentrations of SrBHA powder and the effects on the mechanical properties of the composites were investigated. The composites were fabricated using twin-screw extruders and compressed into test specimens using compression molding machinery. When the SrBHA powder concentration was <10 phr, the SrBHA particles were uniformly dispersed throughout the composite via a continuous polymer matrix reaction. Moreover, this concentration produced the greatest increase in compressive strength compared to the sample with no SrBHA (127.4 MPa). The composites were analyzed using energy-dispersive X-ray analysis, Fourier-transform infrared spectroscopy, and X-ray diffraction to determine the dispersion of the reinforced nanoparticles. Scanning electron microscopy (SEM) was used to analyze the dispersion of the SrBHA powder inside the matrix and to determine the causes of the fractures. The SrBHA powder improved the mechanical properties of PMMA, which is critical for applications in biomedical components. The mechanical tests and SEM analysis indicated that PMMA/SrBHA composites could be used for replacement joints and orthopedic implants.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The 45S Bioactive glass-ceramic (BG) and Chromium (Cr)-doped BG materials were successfully produced in this study. XRD, FTIR, and ICP-MS techniques were used to characterize the prepared materials. The XRD testing showed that all samples contained pure BG. Increased Cr ion inclusion shifted the BG diffraction peaks to a lower value of 2 Theta and increased crystallinity. FTIR was used to detect Si-O, P-O, and Ca-O functional groups. Cr ions steadily decreased the Ca-vibration mode area. The ultraviolet-visible spectrophotometry was used to measure the optical characteristics of pure and Cr BG-doped materials. The Cr-doped BG was green in colour, whereas the lab-synthesized BG was white. Two additional bands formed at 433 and 615 nm when Cr ions were doped into the BG structure. These bands may be caused by 4A2 → 4T1 and 4A2 → 4T2 electronic d-d transitions. The findings show that biomedical applications may exist for fluorescent probes manufactured from Cr-BG materials.
{"title":"Preparation, Characterization and Optical Analysis of Chromium Doped 45S Bioactive Glass-Ceramic","authors":"I. S. Çardaklı","doi":"10.4028/p-pihx2j","DOIUrl":"https://doi.org/10.4028/p-pihx2j","url":null,"abstract":"The 45S Bioactive glass-ceramic (BG) and Chromium (Cr)-doped BG materials were successfully produced in this study. XRD, FTIR, and ICP-MS techniques were used to characterize the prepared materials. The XRD testing showed that all samples contained pure BG. Increased Cr ion inclusion shifted the BG diffraction peaks to a lower value of 2 Theta and increased crystallinity. FTIR was used to detect Si-O, P-O, and Ca-O functional groups. Cr ions steadily decreased the Ca-vibration mode area. The ultraviolet-visible spectrophotometry was used to measure the optical characteristics of pure and Cr BG-doped materials. The Cr-doped BG was green in colour, whereas the lab-synthesized BG was white. Two additional bands formed at 433 and 615 nm when Cr ions were doped into the BG structure. These bands may be caused by 4A2 → 4T1 and 4A2 → 4T2 electronic d-d transitions. The findings show that biomedical applications may exist for fluorescent probes manufactured from Cr-BG materials.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141813839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Eugenio, Arra Jane De Guzman, Eduardo L. Sanidad, Sunshine C. Asuncion, Roseanne G. Dela Cruz, Paulo B. Patricio, Benedick A. Peralta, Harvey D. Torres, J. Monserate
Gold nanoparticles (AuNPs) have garnered significant interest in the field of biomaterials and biomedical engineering due to their wide-ranging applications, excellent biocompatibility, low toxicity, and customizable stability. This study focuses on synthesizing AuNPs through an environmentally friendly approach, specifically by utilizing the aqueous leaf extract of Allium tuberosum as both a reducing and capping agent. The synthesized AuNPs were characterized using UV-Vis Spectroscopy, revealing an absorption peak at 548 nm within the surface plasmon resonance (SPR) of AuNPs. Morphological analysis conducted via SEM showed a mixture of rod-shaped and spherical-shaped AuNPs, with dimensions of 41.0 nm (width) and 181.6 nm (length) confirmed through DLS measurements. EDX analysis confirmed the high abundance of gold in the synthesized AuNPs. Furthermore, a zeta potential value of -26.2 mV indicates that the AuNPs have decent stability. Phytochemical analyses and FT-IR results implicated that the Saponin present in the Allium tuberosum leaf extract played a crucial role in reducing metal ions and stabilizing the AuNPs. The potential of Allium tuberosum leaf extract for synthesizing diverse metal nanoparticles highlights its promise for biomaterials and biomedical engineering. The synthesized AuNPs show versatility for applications like targeted drug delivery, non-invasive imaging, and emerging biomedical uses.
{"title":"Green Synthesis of Gold Nanoparticles using Aqueous Extract of Allium tuberosum Leaves","authors":"P. Eugenio, Arra Jane De Guzman, Eduardo L. Sanidad, Sunshine C. Asuncion, Roseanne G. Dela Cruz, Paulo B. Patricio, Benedick A. Peralta, Harvey D. Torres, J. Monserate","doi":"10.4028/p-4dixjm","DOIUrl":"https://doi.org/10.4028/p-4dixjm","url":null,"abstract":"Gold nanoparticles (AuNPs) have garnered significant interest in the field of biomaterials and biomedical engineering due to their wide-ranging applications, excellent biocompatibility, low toxicity, and customizable stability. This study focuses on synthesizing AuNPs through an environmentally friendly approach, specifically by utilizing the aqueous leaf extract of Allium tuberosum as both a reducing and capping agent. The synthesized AuNPs were characterized using UV-Vis Spectroscopy, revealing an absorption peak at 548 nm within the surface plasmon resonance (SPR) of AuNPs. Morphological analysis conducted via SEM showed a mixture of rod-shaped and spherical-shaped AuNPs, with dimensions of 41.0 nm (width) and 181.6 nm (length) confirmed through DLS measurements. EDX analysis confirmed the high abundance of gold in the synthesized AuNPs. Furthermore, a zeta potential value of -26.2 mV indicates that the AuNPs have decent stability. Phytochemical analyses and FT-IR results implicated that the Saponin present in the Allium tuberosum leaf extract played a crucial role in reducing metal ions and stabilizing the AuNPs. The potential of Allium tuberosum leaf extract for synthesizing diverse metal nanoparticles highlights its promise for biomaterials and biomedical engineering. The synthesized AuNPs show versatility for applications like targeted drug delivery, non-invasive imaging, and emerging biomedical uses.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140717546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Orthopedic cement is an essential component of cemented Total Hip Replacements (THR). It must ensure three essential functions: very good implant-cement adhesion, good bone-implant load transfer, and good antibiotic transport. The main objective of the present work is to study the fracture behavior of orthopedic cement in total hip replacements. The analysis is performed using the submodel technique. Two cases are being considered. The first case involves ordinary cracks, while the second case involves cracks emanating from cavities in the cement of the THR acetabular part. The effects of crack position and implant orientation on the variation of stress intensity factors (SIF) in the three failure modes are discussed. It has also been shown that the circumferential positions of cracks present a major risk of loosening of the prosthesis, especially when the defect is aligned with its axis.
{"title":"Analysis of the Fracture Behavior of Orthopedic Cement Using Submodeling Technique","authors":"Bachir Gasmi, B. Aour, S. Benbarek, A. Talha","doi":"10.4028/p-io8hnf","DOIUrl":"https://doi.org/10.4028/p-io8hnf","url":null,"abstract":"Orthopedic cement is an essential component of cemented Total Hip Replacements (THR). It must ensure three essential functions: very good implant-cement adhesion, good bone-implant load transfer, and good antibiotic transport. The main objective of the present work is to study the fracture behavior of orthopedic cement in total hip replacements. The analysis is performed using the submodel technique. Two cases are being considered. The first case involves ordinary cracks, while the second case involves cracks emanating from cavities in the cement of the THR acetabular part. The effects of crack position and implant orientation on the variation of stress intensity factors (SIF) in the three failure modes are discussed. It has also been shown that the circumferential positions of cracks present a major risk of loosening of the prosthesis, especially when the defect is aligned with its axis.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This research paper investigates the application of a Double Gate (DG) Tunnel Field-Effect Transistor (DG-TFET) for the detection of cell lines derived from breast cancer tissue, namely Hs578T, MDA-MB-231, MCF-7, and T47D. The device incorporates two nanocavities positioned beneath the two gate electrodes, significantly enhancing detection capabilities. The study emphasizes the differentiation between healthy non-tumorigenic cells (MCF-10A) and breast cancer-derived cell lines by incorporating gate engineering into the TFET. Furthermore, the research explores the impact of changes in dielectric values specific to different breast malignant cell types on the biosensor's detection capabilities. Additionally, the investigation delves into the influence of variations in device geometry, including cavity dimensions and dielectric layer thickness, on critical parameters such as drain current sensitivity, transconductance sensitivity, and ION/IOFF sensitivity. Sensitivity analysis concerns drive current, ION/IOFF ratio, threshold voltage (Vth), and transconductance. The structural design of the device is tailored to facilitate array-based diagnosis and screening of cell lines derived from breast cancer tissue. This design offers several advantages, including a simplified transduction process, compatibility with CMOS processes, cost-effectiveness, reproducibility, and adjustable electrical responses. The researchers employed ATLAS, a two-dimensional (2D) device simulator from Silvaco, to model and define the device structure. The numerical simulations validate the device's performance, demonstrating favorable ON-OFF transition profiles.
{"title":"Design and Evaluation of a Double-Gate Tunnel Field Effect Transistor for the Detection of Breast Cancer Cells","authors":"P. Vimala, Salman Saleem, T. Samuel","doi":"10.4028/p-nku9ik","DOIUrl":"https://doi.org/10.4028/p-nku9ik","url":null,"abstract":"This research paper investigates the application of a Double Gate (DG) Tunnel Field-Effect Transistor (DG-TFET) for the detection of cell lines derived from breast cancer tissue, namely Hs578T, MDA-MB-231, MCF-7, and T47D. The device incorporates two nanocavities positioned beneath the two gate electrodes, significantly enhancing detection capabilities. The study emphasizes the differentiation between healthy non-tumorigenic cells (MCF-10A) and breast cancer-derived cell lines by incorporating gate engineering into the TFET. Furthermore, the research explores the impact of changes in dielectric values specific to different breast malignant cell types on the biosensor's detection capabilities. Additionally, the investigation delves into the influence of variations in device geometry, including cavity dimensions and dielectric layer thickness, on critical parameters such as drain current sensitivity, transconductance sensitivity, and ION/IOFF sensitivity. Sensitivity analysis concerns drive current, ION/IOFF ratio, threshold voltage (Vth), and transconductance. The structural design of the device is tailored to facilitate array-based diagnosis and screening of cell lines derived from breast cancer tissue. This design offers several advantages, including a simplified transduction process, compatibility with CMOS processes, cost-effectiveness, reproducibility, and adjustable electrical responses. The researchers employed ATLAS, a two-dimensional (2D) device simulator from Silvaco, to model and define the device structure. The numerical simulations validate the device's performance, demonstrating favorable ON-OFF transition profiles.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：